Analysis of rab GTPases.

Rab GTPases as coordinators of vesicle traffic - Nature

Rab GTPases control all aspects of intracellular vesicle trafficking by acting as regulatable switches that recruit effector molecules when ...

Rab family of small GTPases: an updated view on their regulation ...

The Rab family of small GTPases regulates intracellular membrane trafficking by orchestrating the biogenesis, transport, tethering, and fusion of ...

Comprehensive knockout analysis of the Rab family GTPases in ...

We generated a comprehensive collection of knockout (KO) MDCK cells for the entire Rab family. We knocked out closely related paralogs simultaneously.

Systematic functional analysis of rab GTPases reveals limits ... - eLife

The first complete null mutant collection of all rab GTPase genes in a multicellular organism uncovers neuronal development and function ...

Analysis of rab GTPases - PubMed

This unit describes methods to identify proteins interacting with, and regulating, Rab GTPases. Rabs form the largest subgroup of Ras superfamily GTPases, ...

Rab GTPases: master regulators that establish the secretory and ...

Prenylome-wide analysis later revealed that a single cell might contain at least 42 different Rabs (Nguyen et al., 2009); other Rabs are ...

Untangling the evolution of Rab G proteins - BMC Biology

In this study, we used a classification and phylogeny-based approach to define subfamilies of the Rab proteins, and then iteratively built and ...

Interaction analysis of prenylated Rab GTPase with Rab ... - PNAS

Prenylation, membrane delivery, and recycling of all 60 members of the Rab GTPase family are regulated by two related molecules, Rab escort protein (REP) and ...

Rab GTPases and Membrane Trafficking in Neurodegeneration

Alterations of Rab GTPases, or the membrane compartments they regulate, are associated with virtually all neuronal activities in health and ...

Analysis of Rab GTPases - Langemeyer - 2012 - Current Protocols

The following protocols describe methods to identify proteins interacting with Rab GTPases. The yeast-2-hybrid protocol (see Basic Protocol 1) ...

A comprehensive analysis of Rab GTPases reveals a role for Rab34 ...

These findings suggest that Rab34 is an atypical Rab that regulates serum starvation-induced ciliogenesis through its unique N-terminal region.

Structural Clues to Rab GTPase Functional Diversity - ScienceDirect

Rab GTPases are key regulators of membrane trafficking in eukaryotes. Recent structural analysis of a number of Rabs, either alone or in complex with ...

Rab GTPases and membrane identity: Causal or inconsequential?

Analysis of Rab GTPases themselves suggests a pattern of evolution of Rabs consistent with the evolution of a core set of membrane ...

Role of Rab GTPases in Membrane Traffic and Cell Physiology

A recent study indicated that 42 Rab GTPases are expressed in COS7 cells, with the abundant Rabs being those that regulate endocytosis, secretion, and ...

Full article: Rab GTPases and their interacting protein partners

Rabs work as typical Ras-like small GTPases. They are nucleotide dependent molecular switches that are ON in the GTP-bound (active) form and OFF in the GDP- ...

Toward a Comprehensive Map of the Effectors of Rab GTPases

The Rab GTPases recruit peripheral membrane proteins to intracellular organelles. These Rab effectors typically mediate the motility of organelles and ...

The Rab GTPase family | Genome Biology | Full Text - BioMed Central

The Rab GTPases are a large family of proteins with a variety of regulatory functions in membrane traffic. The central role of these proteins ...

Functional analysis of CLPT1, a Rab/GTPase required for protein ...

In eukaryotic cells, Rab/GTPases are major regulators of vesicular trafficking and are involved in essential processes including exocytosis, endocytosis.

The Interaction Properties of the Human Rab GTPase Family - PLOS

This analysis assists the functional annotation of Rab proteins 12, 14, 26, 37 and 41 and provided an explanation for the shared function of Rab3 and 27. Rab7a ...

Analysis of rab GTPases. - ORA - Oxford University Research Archive

This unit describes methods to identify proteins interacting with, and regulating, Rab GTPases. Rabs form the largest subgroup of Ras superfamily GTPases, ...