Antagonism of Platelet|Derived Growth Factor Receptor in Non ...

Antagonism of platelet-derived growth factor receptor in non small ...

Preclinical data show that platelet-derived growth factor receptor antagonism decreases interstitial fluid pressure, augments intratumoral concentration of ...

Antagonism of Platelet-Derived Growth Factor Receptor in Non ...

Imatinib is also a potent inhibitor of the platelet-derived growth factor receptor. The platelet-derived growth factor receptor is crucial in ...

Antagonism of Platelet-Derived Growth Factor Receptor in Non ...

Antagonism of Platelet-Derived Growth Factor Receptor in. Non ^ Small Cell Lung Cancer: Rationale and Investigations. Julie E. Bauman, Keith D ...

Platelet-derived growth factors and their receptors: structural and ...

The four types of platelet-derived growth factors (PDGFs) and the two types of PDGF receptors (PDGFRs, which belong to class III receptor tyrosine kinases) have ...

Antagonism of platelet-derived growth factor receptor in non

Antagonism of platelet-derived growth factor receptor in non - small cell lung cancer: Rationale and investigations · Overview · Fingerprint ...

Involvement of platelet‐derived growth factor ligands and receptors ...

Moreover, PDGF stimulates cells in tumour stroma and promotes angiogenesis as well as the development of cancer-associated fibroblasts, both of ...

Use of multitarget tyrosine kinase inhibitors to attenuate platelet ...

Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) represent one of the most intensively studied families of signalling factors over the past ...

Prognostic Impact of Platelet-Derived Growth Factors in Non-small ...

PDGF ligands and receptors are of major importance in angiogenesis.10, 11, 12 PDGF-B and PDGFR-β is required for recruitment of pericytes ...

Platelet-Derived Growth Factor Receptor - ScienceDirect.com

Platelet-derived growth factor binds to specific receptors expressed on the surfaces of target cells (Bowen-Pope and Ross, 1982 Huang et al., 1982 · PDGF–PDGF ...

Targeting the PDGF signaling pathway in tumor treatment

Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important functions in the regulation of growth and survival of ...

Platelet-Derived Growth Factor (PDGF)/PDGF Receptors (PDGFR ...

The molecular mechanisms of PDGF/PDGFR-mediated angiogenesis are not fully understood, but it was shown that tyrosine kinase inhibitors reduce tumor growth and ...

B Monoclonal Antibody, MOR8457, Reveals Conformational ...

Platelet derived growth factor-BB (PDGF-BB) is an important mitogen and cell survival factor during development. PDGF-BB binds PDGF receptor-β to trigger ...

Platelet-derived growth factor receptor - Wikipedia

Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family ...

Platelet-Derived Growth Factor Receptor-β Antagonism Restores ...

We previously demonstrated that platelet-derived growth factor- β (PDGFR-β) inhibition completely eliminated morphine tolerance. In these studies, we determined ...

Platelet-derived growth factor receptor β activation and regulation in ...

We therefore focused on regulation of PDGFRβ by protein tyrosine phosphatases as endogenous PDGFRβ antagonists. Gene expression analyses showed distinct ...

platelet derived growth factor receptor alpha | Type III RTKs

We have mapped PDGF receptor tyrosine kinase inhibitor II to the alpha subunit of the PDGFR [18], but as the experiments were carried out in intact cells, it is ...

Differential prognostic impact of platelet-derived growth factor ...

The three known dimeric PDGF receptor combinations, PDGFR-αα, PDGFR-αβ, and PDGFR-ββ, transduce overlapping but not identical cellular signals.

Mechanism of Action and In Vivo Role of Platelet-Derived Growth ...

GTPase activating protein binds to PDGF β-receptors but not to α-receptors (178). It converts Ras · GTP to Ras · GDP and thus has a modulatory role in Ras ...

Platelet-derived growth factor (PDGF) cross-signaling via non ...

PDGF and its receptors are expressed in colon cancer cells as well as surrounding tissue [26, 28, 29], implying the possibility of autocrine ...

Sphingosine 1-Phosphate Transactivates the Platelet-Derived ...

We show that platelet-derived growth factor β receptor (PDGFβR) and EGFR are tyrosine phosphorylated in response to S1P in rat aortic vascular smooth muscle ...