Antagonism of platelet|derived growth factor receptor in non small ...

Antagonism of platelet-derived growth factor receptor in non small ...

Preclinical data show that platelet-derived growth factor receptor antagonism decreases interstitial fluid pressure, augments intratumoral concentration of ...

Antagonism of Platelet-Derived Growth Factor Receptor in Non ...

Preclinical data show that platelet-derived growth factor receptor antagonism decreases interstitial fluid pressure, augments intratumoral ...

Antagonism of Platelet-Derived Growth Factor Receptor in Non ...

Two phase II studies in advanced non ^ small cell lung cancer are currently under way with imatinib. The first trial evaluates the use of ...

Prognostic Impact of Platelet-Derived Growth Factors in Non-small ...

Platelet-derived growth factors (PDGFs) and receptors (PDGFRs) are pivotal in this interaction, and important targets in novel antiangiogenic therapies. This ...

Potential role of platelet-derived growth factor receptor inhibition ...

Potential role of platelet-derived growth factor receptor inhibition using imatinib in combination with docetaxel in the treatment of recurrent non-small cell ...

Antagonism of platelet-derived growth factor receptor in non - small ...

Dive into the research topics of 'Antagonism of platelet-derived growth factor receptor in non - small cell lung cancer: Rationale and investigations'. Together ...

Platelet-derived growth factor receptor inhibitors for non-small cell ...

1. Targeting PDGF pathway in non-small cell lung cancer ... [Citation2] Given the crucial role of angiogenesis in lung cancer development and proliferation, a ...

Potential Role of Platelet-Derived Growth Factor Receptor Inhibition ...

Platelet-derived growth factor receptor (PDGFR) is expressed in lung cancer and is involved in angiogenesis. Preclinical models demonstrated that imatinib ...

Differential prognostic impact of platelet-derived growth factor ...

Preclinical evidence suggests that stromal expression of platelet-derived growth factor receptors (PDGFRs) stimulates tumor development and ...

Use of multitarget tyrosine kinase inhibitors to attenuate platelet ...

Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) play a fundamental role in the embryonic development of the lung.

Potential Role of Platelet-Derived Growth Factor Receptor Inhibition ...

Key Words: Imatinib, Docetaxel, Platelet-derived growth factor receptor, Recurrent Lung cancer. (J Thorac Oncol. 2011;6: 372–377). Advanced non-small cell lung ...

Involvement of platelet‐derived growth factor ligands and receptors ...

Notably, imatinib does not pass the brain–blood barrier and therefore fails to target most of the invading tumour cells. Another factor that ...

Targeting the PDGF signaling pathway in tumor treatment

Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important functions in the regulation of growth and survival of ...

Inhibition of Platelet-Derived Growth Factor Receptor α by MEDI-575 ...

We used the Calu-6 non-small cell lung cancer model because it lacks an in vitro proliferative response to PDGFRα activation. Antitumor activity ...

Platelet-Derived Growth Factor (PDGF)/PDGF Receptors (PDGFR ...

The molecular mechanisms of PDGF/PDGFR-mediated angiogenesis are not fully understood, but it was shown that tyrosine kinase inhibitors reduce tumor growth and ...

Antagonism of Platelet-Derived Growth Factor Receptor in Non ...

Antagonism of Platelet-Derived Growth Factor Receptor in Non–Small Cell Lung Cancer: Rationale and Investigations. Julie E. Bauman. ,. Keith D. Eaton.

The platelet-derived growth factor receptor as a therapeutic target

Several small molecule tyrosine kinase inhibitors that block the epidermal growth factor receptor and vascular endothelial growth factor ...

platelet derived growth factor receptor alpha | Type III RTKs

We have mapped PDGF receptor tyrosine kinase inhibitor II to the alpha subunit of the PDGFR [18], but as the experiments were carried out in intact cells, it is ...

B Monoclonal Antibody, MOR8457, Reveals Conformational ...

Platelet derived growth factor-BB (PDGF-BB) is an important mitogen and cell survival factor during development. PDGF-BB binds PDGF receptor-β to trigger ...

Anti-platelet derived growth factor receptor - Sigma-Aldrich

Platelet-derived growth factor receptor β (PDGFRβ) is a receptor tyrosine kinase which upon activation by PDGF-BB stimulates cell ...