Antibody|based redirection of universal Fabrack|CAR T cells ...

Antibody-based redirection of universal Fabrack-CAR T cells ...

These studies demonstrate antigen- and antibody-specific T cell activation, proliferation, and IFNγ production, selective killing of target cells in a mixed ...

Antibody-based redirection of universal Fabrack-CAR T cells ...

Citation. Kuo Y, Kuo C, Jenkins K, et al. Antibody-based redirection of universal Fabrack-CAR T cells selectively kill antigen bearing tumor ...

Universal redirection of CAR T cells against solid tumours via ...

The effectiveness of chimaeric antigen receptor (CAR) T cell therapies for solid tumours is hindered by difficulties in the selection of an ...

Antibody-based redirection of universal Fabrack-CAR T cells ...

method: We constructed a universal Fabrack-CAR with an extracellular domain composed of the non-tumor targeted, cyclic, twelve residue meditope peptide that ...

Redirecting CAR T-Cell Specificity with A Universal and Adaptable ...

We described a novel CAR T-cell adapter platform that relies on a bispecific antibody (BsAb) targeting both a tumor antigen and the GGGGS (G 4 S) linker.

Redirecting CAR T-Cell Specificity with A Universal and Adaptable ...

Herein, we described a novel CAR T-cell adapter platform that relies on a bispecific antibody (BsAb) targeting both a tumor antigen and the ...

In situ antigen modification-based target-redirected universal ...

Chimeric antigen receptor (CAR)-T cell therapy has demonstrated remarkable success in the treatment of hematologic malignancies, ...

Antibody-based redirection of universal Fabrack-CAR T cells ... - OUCI

BackgroundChimeric antigen receptor (CAR) T cells engineered to recognize and target tumor associated antigens have made a profound impact on the quality of ...

of Genetically Engineered CAR-T Cells Using Bifunctional Small ...

Conduit CAR: Redirecting CAR T-Cell Specificity with A Universal and Adaptable Bispecific Antibody Platform. Cancer Research Communications ...

Rapidly Switchable Universal CAR-T Cells for Treatment of CD123 ...

The application of monoclonal antibodies (mAbs),, redirection of autologous T cells with bispecific antibodies, and cellular immunotherapy demonstrated high ...

Identification of Targets to Redirect CAR T Cells in Glioblastoma and ...

Finally, we will discuss current knowledge of altered glycosylation of CSCs and cancer cells and how these novel epitopes may help to target CAR T cell-based ...

The construction of modular universal chimeric antigen receptor T ...

The Sd/Gv-based CAR effectively redirected T cells to eliminate target cells. A Schematic representation of the design of modular CAR by Sd/Gv ...

T cells engineered to express a CD19-specific chimeric-antigen ...

A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of ...

Engineering strategies to overcome the current roadblocks in CAR T ...

4Db), which are also known as T cells redirected for universal cytokine killing (TRUCKs). ... A foundation for universal T-cell based ...

(PDF) Redirection of Genetically Engineered CAR-T Cells Using ...

PDF | Chimeric antigen receptor (CAR)-engineered T cells (CAR-Ts) provide a potent anti-tumor response and have become a promising treatment ...

Antibody-based redirection of universal Fabrack-CAR T cells ...

Antibody-based redirection of universal Fabrack-CAR T cells selectively kill antigen bearing tumor cells. J Immunother Cancer. 2022-06;. Yi-Chiu Kuo, Cheng-Fu ...

CAR T Cells: Engineering Immune Cells to Treat Cancer - NCI

Research on CAR T-cell therapy is progressing rapidly to improve the cancer treatment, expand its use to more cancers, and better manage its ...

The UniCAR system: A modular CAR T cell approach to improve the ...

Targeted antibody-mediated depletion of murine CD19 CAR T cells ... redirection of human regulatory t cells via a novel universal chimeric antigen receptor system.

next-generation CAR modifications for enhanced T-cell function ...

... to create a ligand-based CAR or universal CAR. The ligand-based CAR replaces ... Redirecting gene-modified T cells toward various cancer types using tagged ...

Chimeric Antigen Receptor–Modified T Cells and T Cell–Engaging ...

Both BiAb and CAR T cells use antibodies or antibody fragments to redirect T cells ... Multiplex genome editing to generate universal CAR T cells ...