Anticancer drugs are not well tolerated in all older patients with cancer

Studies on new anticancer drugs often inappropriately conclude that these treatments are well tolerated and feasible in the older population with cancer.

anticancer drugs for older people with cancer. ... drug–drug interactions that can lead to non-eligibility. ... automatically excluded based solely ...

Safety of solid oncology drugs in older patients: a narrative review

Antibody–drug conjugates. ADCs are a novel class of anticancer agents that combine mAbs with potent cytotoxic drugs, offering targeted therapy ...

Targeted Therapies in Older Adults With Solid Tumors - PMC

... older adults with cancer, these agents are often used with ... Wildiers H, de Glas NA.Anticancer drugs are not well tolerated in all ...

Why Cancer Treatments Might Not Work Very Well for Older Adults

... chemotherapy, radiation, and a drug targeting a specific genetic ... older patients' ability to tolerate unknown side effects of new drugs.

Understanding Treatment Tolerability in Older Adults With Cancer

... drug interactions on treatment completion and prognosis in older patients with ovarian cancer. ... geriatric oncology: One size does not fit all.

Safety of solid oncology drugs in older patients: a narrative review

Antibody–drug conjugates. ADCs are a novel class of anticancer agents that combine mAbs with potent cytotoxic drugs, offering targeted therapy with potentially ...

Tolerance to oral anticancer agent treatment in older adults with ...

More than 60% of cancer cases occur in older adults, and many are treated with oral anticancer agents. ... drug events in cancer patients: a ...

Oncology Geriatrics Pharmacy and Clinical Pharmacology Toxicology Adverse Drug Events Clinical Pharmacy and Pharmacology ... NOT fit all ...

Is cancer biology different in older patients? - The Lancet

27. Wildiers, H ∙ de Glas, NA. Anticancer drugs are not well tolerated in all older patients with cancer. Lancet Healthy Longev. 2020; 1:e43-e47. Full Text.

Treatment Modification and Tolerability Among Older Chemotherapy ...

All of the planned regimens (individual drugs, doses, and ... FDA Analysis of Enrollment of Older Adults in Clinical Trials for Cancer Drug ...

Geriatric Assessment Reduces Cancer Treatment Side Effects - NCI

For example, 23% of people in the intervention group compared with 18% of those in the usual care group received a single chemotherapy drug ...

Immunotherapy in Older Adults With Advanced Cancers

Immunotherapy has expanded the therapeutic landscape for advanced cancers, including solid tumors and lymphomas. For many patients with cancer, these agents ...

Efforts to Lower Cancer Drug Doses Gain Steam - NCI

If the dosage of the approved drug is not optimal, that may affect both its efficacy and safety when used along with other drugs. “The majority ...

Triple-negative breast cancer in the older population

It should be noted that it is not possible to provide strict guidelines on which agents to use for TNBC in older patients. As treatment in this setting is ...

What's new in oncology - UpToDate

The drug was well tolerated. Based on these results, an international ... Given the recent guidelines and data, we do not use wakefulness agents in ...

Non-small Cell Lung Cancer Chemotherapy | Chemo Side Effects

Targeted Drug Therapy for Non-Small Cell Lung Cancer · Immunotherapy ... Chemotherapy drugs used to treat NSCLC. The chemo drugs most ...

5-Safe administration of anti-cancer drugs | eviQ

Specific considerations for vesicant anti-cancer drugs ; During the administration of a vesicant drug: for bolus infusions, staff should remain at the patient's ...

Breast cancer in the elderly—Should it be treated differently?

A lower GFR is of particular concern in the case of drugs and drug metabolites whose clearance depends heavily on renal excretion (includ- ing such drugs as ...

Targeting cancer metabolism in the era of precision oncology - Nature

It is notable, however, that the deployment of these drugs does not ... JPH203, a newly developed anti-cancer drug, shows a preincubation ...