Antigen|specific CD4 T cells exhibit distinct transcriptional ...

Antigen-specific CD4+ T cells exhibit distinct transcriptional ...

Our findings provide an atlas of human antigen-specific CD4 + T cell transcriptional phenotypes in the dLN and blood following vaccination or infection.

Antigen-specific CD4+ T cells exhibit distinct transcriptional ... - NCBI

Antigen-specific CD4 + T cells exhibit distinct transcriptional phenotypes in the lymph node and blood following vaccination in humans.

Antigen-Specific CD4+ T Cells Exhibit Distinct Kinetic and ... - Frontiers

Although CD4+ T cell memory is a critical component of adaptive immunity, antigen-specific CD4+ T cell recall responses to secondary infection ...

CD4+ T cells display a spectrum of recall dynamics during re ...

Polyclonal, TCR-diverse, CD4+ T cells exhibit similar recall dynamics, with individual clones giving rise to multiple effectors including highly ...

Distinctive populations of CD4+T cells associated with vaccine efficacy

To distinguish features of memory cells that confer protective immunity, we used single cell transcriptome analysis to compare antigen-specific ...

Antigen affinity and antigen dose exert distinct influences on CD4 T ...

T-cell receptor recognition of antigen is an essential first step in the initiation of a T-cell response. This report demonstrates that CD4 T cells ...

Autoantigen-specific CD4+ T cells acquire an exhausted phenotype ...

Pro-inflammatory autoantigen-specific CD4+ T helper (auto-Th) cells are central orchestrators of autoimmune diseases (AIDs).

CD4+ T cell memory | Nature Immunology

These diverse roles are accomplished by developmental specification events that result in unique CD4+ T cell lineages and differentiation states ...

Transcriptional and functional analyses of neoantigen-specific CD4 ...

Indeed, CD4 T cells were identified that selectively recognized five different neoantigens from this patient. These neoantigen-specific T cells actively ...

The amalgam of naive CD4+ T cell transcriptional states is ...

Naive CD4+ T cells in specific pathogen-free (SPF) mice are characterized by transcriptional heterogeneity and subpopulations distinguished ...

Distinct functions of antigen-specific CD4 T cells during murine ...

PD-1–expressing CD4 T cells were highly proliferative, whereas KLRG1 cells exhibited a short lifespan and secreted the cytokines IFNγ and TNFα.

An atlas of mouse CD4+ T cell transcriptomes - Biology Direct

effector subtypes that exhibit distinct functions. The transcriptional mechanisms that underlie the specific functional identity of CD4+ T cells ...

Naive CD4+ T Cells Exhibit Distinct Expression Patterns of ...

In this study we have investigated the primary response of naive CD4+ T cells derived from OVA-specific TCR-transgenic mice (OVA23-3) upon stimulation with ...

Antigen-specific depletion of CD4+ T cells by CAR T cells reveals ...

Both higher- and lower-affinity self-reactive CD4+ T cells are expanded in autoimmunity; however, their individual contribution to disease ...

Entrance to the multifaceted world of CD4+ T cell subsets

Overall, Th9 cells represent a unique subset of CD4+ T cells with a specific cytokine profile and transcriptional regulation, implicated in various diseases ...

Rapid induction of antigen-specific CD4 + T cells is associated with ...

AIM+ CD8+ T cells had a similar subset distribution to AIM+ CD4+ T cells. The baseline antigen-specific CD8+ T cell response in recovered subjects was composed ...

CD8 + chimeric antigen receptor T cells manufactured in absence of ...

Results We found that the coculture of CD8+ CAR T cells with CD4+ cells markedly improves CD8+ cell expansion, and further discovered that CD8+ cells cultured ...

Delineating the transcriptional landscape and clonal diversity of ...

CD4+ T cells responding to chronic lymphocytic choriomeningitis virus infection display transcriptional heterogeneity that is marked by both ...

The Era of Cytotoxic CD4 T Cells - Frontiers

Upon activation, naïve CD4 T cells can differentiate into various specialized subsets characterized by the capacity to produce specific cytokines to promote ...

Cutting Edge: CD4 and CD8 T Cells Are Intrinsically Different in ...

In this study, we compared the proliferation and differentiation of Ag-specific CD4 and CD8 T cells following Listeria infection. Our results show that CD4 ...