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Antigen affinity and antigen dose exert distinct influences on CD4 T ...


Antigen affinity and antigen dose exert distinct influences on CD4 T ...

This report demonstrates that CD4 T cells responding during an infection can discriminate between antigen affinity and antigen dose, resulting in distinct ...

Antigen affinity and antigen dose exert distinct influences on CD4 T ...

Cumulative T-cell receptor signal strength and ensuing T-cell responses are affected by both antigen affinity and antigen dose.

Antigen affinity and antigen dose exert distinct influences on CD4 T ...

These data reveal that antigen affinity exerts an important influence on T-cell differentiation that is not compensated for by high antigen dose ...

Antigen affinity and antigen dose exert distinct influences on CD4 T ...

Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation. Keck S, Schmaler M, Ganter S, Wyss L, Oberle S, Huseby ES, Zehn D ...

Antigen affinity and antigen dose exert distinct influences on CD4 T ...

These data reveal that antigen affinity exerts an important influence on T-cell differentiation that is not compensated for by high antigen dose. Understanding ...

Antigen affinity and antigen dose exert distinct influences on CD4 T ...

Here we examined the distinct contributions of these parameters to CD4 T-cell differentiation during infection. We found that high antigen affinity positively ...

Antigen affinity and antigen dose exert distinct influences on CD4 T ...

Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation Check holdings James A. Cannavino Library Periodicals Hardcopy ...

(PDF) Antigen affinity and antigen dose exert distinct influences on ...

Here we examined the distinct contributions of these parameters to CD4 T-cell differentiation during infection. We found that high antigen affinity positively ...

Antigen affinity and antigen dose exert distinct influences on CD4 T ...

Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation. Simone Keck, Mathias Schmaler, Stefan Ganter, Lena Wyss, Susanne ...

CD4 T cell affinity diversity is equally maintained during acute and ...

In comparison to an acute infection, understanding how the chronic infection environment shifts and shapes the host's antigen specific CD4 T cell populations' ...

CD4+ T cell memory | Nature Immunology

The detection of low-affinity CD4+ T cells can be improved by further increasing the valency, as demonstrated by dodecamers. Recently developed ...

Complete but curtailed T-cell response to very low-affinity antigen.

Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation. Keck S et al.2014 Oct 14. Latest recommendation by: avatar image.

Regulation of T Helper Cell Fate by TCR Signal Strength - Frontiers

Naïve CD4+ T cells are activated when their unique T cell Receptor (TCR) recognizes cognate peptides presented by Major Histocompatibility Complex (MHC) class ...

Opposing effects of T cell receptor signal strength on CD4 T ... - eLife

(2014) Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation. PNAS 111:14852–14857. https://doi.org ...

Low-affinity CD4+ T cells are major responders in the primary ...

These findings demonstrate that affinity for antigen does not control CD4+ T-cell entry into the primary immune response, as a diverse range in ...

Toward a general model of CD4+ T cell subset specification and ...

... antigen-specific T cells. Nat. Biotechnol., 39 ... Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation.

Antigen and checkpoint receptor engagement recalibrates T cell ...

33. Keck, S. ∙ Schmaler, M. ∙ Ganter, S. ... Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation. Proc. Natl. Acad ...

How Does B Cell Antigen Presentation Affect Memory CD4 T Cell ...

Thus, the above observations that B cells, but not DCs, pulsed with low doses of Ag induced resting memory CD4 T cells confirmed prior findings that B cells are ...

Modulating the quantity of HIV Env-specific CD4 T cell help ...

C.G.. King . 2014 . Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation . Proc. Natl. Acad. Sci. USA ...

Antigen affinity and antigen dose exert distinct influences on CD4 T ...

Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation. Item · http://www.wikidata.org/entity/Q34383687.