Antigen receptor control of methionine metabolism in T cells

Antigen receptor control of methionine metabolism in T cells - PubMed

Immune activated T lymphocytes modulate the activity of key metabolic pathways to support the transcriptional reprograming and reshaping of ...

Antigen receptor control of methionine metabolism in T cells - eLife

We show that antigen receptor engagement controls flux through the methionine cycle and RNA and histone methylations.

Antigen receptor control of methionine metabolism in T cells - eLife

Antigen receptor control of methionine transport is critical to co-ordinate protein synthesis and the production of methyl donors for ...

Antigen receptor control of methionine metabolism in T cells

The present study uses high resolution mass spectrometry and metabolic labelling to explore how murine T cells control the methionine cycle to ...

Antigen receptor control of methionine metabolism in T cells

We show that antigen receptor engagement controls flux through the methionine cycle and RNA and histone methylations. We establish that the main rate limiting ...

Antigen receptor control of methionine metabolism in T cells - bioRxiv

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution.

Methionine consumption by cancer cells drives a progressive ...

Reduced methionine increases PD-1 expression on CD4 T cells. The genetic ablation of SLC43A2 in cancer cells restores methionine metabolism in ...

Methionine Metabolism Shapes T Helper Cell Responses through ...

Here we identify methionine as a key nutrient affecting epigenetic reprogramming in CD4+ T helper (Th) cells. Using metabolomics, we showed that ...

Methionine cycle-dependent regulation of T cells in cancer immunity

T cells undergo rapid proliferation and differentiation upon recognition of antigens. Exogenous methionine is required during this process to ...

Antigen receptor control of methionine metabolism in T cells

Dive into the research topics of 'Antigen receptor control of methionine metabolism in T cells'. Together they form a unique fingerprint. Sort by; Weight ...

Methionine cycle-dependent regulation of T cells in cancer immunity

T cells undergo rapid proliferation and differentiation upon recognition of antigens. Exogenous methionine is required during this process to ...

Control of amino-acid transport by antigen receptors coordinates the ...

T lymphocytes must regulate nutrient uptake to meet the metabolic demands of an immune response. Here we show that the intracellular supply ...

A Tug-of-War Over Methionine: Cell Metabolism

In addition to being a building block for proteins, methionine is the primary source of S-adenosyl-methionine (SAM) in T cells. SAM functions as ...

The emerging role of one-carbon metabolism in T cells - ScienceDirect

These findings imply that 1CM and methionine are involved in pathological T cell function. Taken together, the data indicate that activated T ...

Control of T-Cell Activation and Signaling by Amino-Acid ... - Frontiers

During evolution, the production of amino-acid catabolizing enzymes by mainly antigen-presenting cells has become a physiological mechanism to control T-cell ...

A Tug-of-War Over Methionine - ScienceDirect

Amino acid uptake is also elevated in activated T cells, with the essential amino acid methionine being of special interest. Notably, as a ...

Methionine uptake via the SLC43A2 transporter is essential for ...

The metabolic requirements of T-regulatory cells (Tregs) for their survival and how these are satisfied remain unclear. Herein, we identified a ...

Amino acid metabolism in immune cells: essential regulators of the ...

In T cells, antigen signaling mediated through the interaction of the T cell receptor (TCR) and LAT1 increased leucine uptake [32], which may be ...

The importance of methionine metabolism. - Abstract - Europe PMC

The expression of receptors for IL2 – a growth factor that drives proliferation of T cells – is also increased in response to antigen engagement ...

Fueling T-cell Antitumor Immunity: Amino Acid Metabolism Revisited

Schematic diagram summarizing the functional roles of amino acids in T-cell immune responses. 1. Upon antigen stimulation, T-cell receptor ...