Apoptosis Regulators Bcl|2 and Caspase|3

Apoptosis Regulators Bcl-2 and Caspase-3 - MDPI

Apoptosis, programmed cell death, has a central role in developmental biology and in maintaining the equilibrium of renewing tissues.

BAR: An apoptosis regulator at the intersection of caspases and Bcl ...

Results · BAR Is a Multidomain Protein. · BAR Is a Membrane-Associated Protein That Suppresses Bax-Induced Cell Death. · BAR Modulates Bax-Induced Apoptosis ...

(PDF) Apoptosis Regulators Bcl-2 and Caspase-3 - ResearchGate

A founding member of the Bcl-2 family of regulatory proteins for apoptosis is Bcl-2, which is encoded by the BCL2 gene. Caspase-3 shares typical ...

Regulation of apoptosis in health and disease: the balancing act of ...

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome. Nature 419, 6–9 ...

The role of BCL-2 family proteins in regulating apoptosis and cancer ...

... apoptotic proteins of the BCL-2 family participate in the regulation of apoptosis. ... caspases such as caspase-3 and thus induce apoptosis. With respect ...

Pharmacological Targeting of Bcl-2 Induces Caspase 3-Mediated ...

Mitochondria-mediated apoptosis is fundamentally orchestrated by B-cell lymphoma 2 (Bcl-2) family proteins, which are central regulators and ...

Apoptosis Regulators Bcl-2 and Caspase-3 | Encyclopedia MDPI

A founding member of the Bcl-2 family of regulatory proteins for apoptosis is Bcl-2, which is encoded by the BCL2 gene. Caspase-3 shares typical features with ...

Bcl-2 regulates amplification of caspase activation by cytochrome c

11. Cosulich, SC ∙ Worrall, V ∙ Hedge, PJ ... Regulation of apoptosis by BH3 domains in a cell-free system.

Apoptosis regulator, Bcl-2 protein, BH4 (IPR003093) - InterPro entry

Apoptosis, or programmed cell death (PCD), is a common and evolutionarily conserved property of all metazoans · Bcl-2 proteins are central regulators of caspase ...

BCL-2 family isoforms in apoptosis and cancer | Cell Death & Disease

The members of the Bcl-2 family are designated as such due to their BCL-2 homology (BH) domains and involvement in apoptosis regulation. The BH ...

Regulation of apoptosis by BH3 domains in a cell-free system

Results: Using a cell-free system based on extracts of Xenopus eggs, we have investigated the role of the Bcl-2 homology domain 3 (BH3) from different members ...

Apoptosis Regulators Bcl-2 and Caspase-3 - OUCI

Apoptosis, programmed cell death, has a central role in developmental biology and in maintaining the equilibrium of renewing tissues.

Apoptosis Signaling | GeneGlobe - QIAGEN

The main mechanism of action of the BCL-2 family of proteins is the regulation of CYTC release from the mitochondria, which in turn activates caspase 9 and ...

Bax-induced apoptotic cell death - PNAS

In addition, mammalian cells make use of a set of regulatory proteins, the bcl-2 family, which show similarities to the nematode protein CED-9. Consistent with ...

Targeting BCL-2 regulated apoptosis in cancer | Open Biology

However, localization and conformation of BCL-2 proteins is also important in regulation of activity. 3. Pro-survival BCL-2 proteins. Pro- ...

Role of Bcl‐2 family proteins in apoptosis: apoptosomes or ...

Regulation of activities of Bcl-2/Bcl-xL by phosphorylation and caspase-dependent cleavage. The anti-apoptotic activity of Bcl-2 is also ...

Apoptosis regulator, Bcl-X (IPR013279) - InterPro entry - EMBL-EBI

Apoptosis, or programmed cell death (PCD), is a common and evolutionarily conserved property of all metazoans · Bcl-2 proteins are central regulators of caspase ...

Bcl-2 family proteins: master regulators of cell survival - De Gruyter

Each anti-apoptotic Bcl-2 protein has a similar overall helical fold localized on a core hydrophobic helix with the BH1-3 domains arranged to ...

Regulation of stressed-induced cell death by the Bcl-2 family of ...

... 2/3 domains found on the anti-apoptotic Bcl-2 proteins. Various BH3-only ... Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol ...

Bax, Bak and beyond — mitochondrial performance in apoptosis

... Bcl-2 family and core regulators of the intrinsic pathway of apoptosis ... 3B) established a sequence of events for the execution of apoptosis.

BCL2L12

Bcl-2-like protein 12 is a protein that in humans is encoded by the BCL2L12 gene. The protein encoded by this gene belongs to the Bcl-2 protein family.

BCL2L10

Bcl-2-like protein 10 is a protein that in humans is encoded by the BCL2L10 gene. The protein encoded by this gene belongs to the BCL-2 protein family.