Apoptosis and its therapeutic implications in neurodegenerative ...

Neurodegenerative disorders are characterized by progressive loss of particular populations of neurons. Apoptosis has been implicated in the pathogenesis of ...

Neurodegenerative disorders are characterized by progressive loss of particular populations of neurons. Apoptosis has been implicated in the ...

Apoptosis and its therapeutic implications in neurodegenerative ...

This review focuses on the existing notions relevant to comprehending the apoptotic death process, including the morphological features, mediators and ...

Insights on aspects of apoptosis in neurodegenerative disorders

The explosion in research on apoptosis in neurodegeneration has stemmed from the conception that persuading neuronal apoptotic death may be ...

Apoptosis and its Role in Parkinson's Disease - NCBI

Apoptosis is the predominant mode of neuronal death in many neurodegenerative diseases (5, 6), including Parkinson's disease (7). Whilst the pathogenic ...

Insights on aspects of apoptosis in neurodegenerative disorders

However, the significant adverse impact of those pro-apoptotic therapies has prompted researchers to seek ... implications for neurodegenerative.

Apoptosis in neurodegenerative diseases: the role of mitochondria

Recent evidence now indicates that the process of apoptosis rather than necrosis primarily contributes to nerve cell death in neurodegeneration.

Apoptosis and Caspases in Neurodegenerative Diseases

Hypoxia, toxic cytokines, damage to mitochondria, and noxious peptides are capable of inducing apoptosis; each of these mechanisms can account for the death of ...

Potential of Therapeutic Small Molecules in Apoptosis Regulation in ...

Apoptosis is very important in developing the nervous system, nonetheless an elevated level of cell death has been observed in the case of NDs. NDs are ...

Autophagy and apoptosis dysfunction in neurodegenerative disorders

Programmed cell death is crucial for normal neural development (Miura, 2011). It regulates the number and types of cells in the developing brain and spinal cord ...

Apoptosis and its therapeutic implications in neurodegenerative ...

Because apoptosis is required for normal cell turnover and tissue homeostasis, dysregulation of apoptosis at old age is increasingly implicated in various age- ...

Regulated cell death: discovery, features and implications for ...

The completely physiological form of RCD is also known as programmed cell death (PCD) [2]. Neurodegenerative diseases are a variety of ...

Molecular mechanisms of cell death in neurological diseases - Nature

Conversely, inactivation of PCD is thought to contribute to the development of brain cancers and to impact their response to therapy. For many ...

Regulation of mitochondrial dysfunction induced cell apoptosis is a ...

Compared with other diseases, the development of therapeutic drugs for neurodegenerative diseases is relatively slow. Surprisingly, herbal medicine has many ...

Apoptosis and its therapeutic implications in neurodegenerative ...

Additionally, we present evidence of potential therapeutic agents that could modify the apoptotic pathway in the aforementioned neurodegenerative diseases and ...

Significance of Programmed Cell Death Pathways in ... - MDPI

The etiology of neurodegenerative diseases (NDDs) is multifactorial and is associated with abnormalities in various intracellular processes, such as autophagy, ...

The neuroprotective effects of targeting key factors of neuronal cell ...

This review provides an overview of the role of ER stress, oxidative stress, and neuroinflammation in neuronal cell death

Cell death–mediated cytokine release and its therapeutic implications

Targeting apoptosis to treat diseases has seen tremendous success over the past decades. More recently, alternative forms of regulated cell ...

Caspases, Apoptosis, and Alzheimer Disease - Oxford Academic

For example, “Unregulated apoptosis underlies many pathological conditions, including neurodegenerative diseases” (8) and “The loss of hippocampal neurons by ...

Neuronal cell death and neurodegenerative disease | BMG LABTECH

The interplay between these processes contributes to the onset of neurodegenerative disease and eventual neuronal cell death. The consequences ...