Application of Chimeric Mice with Humanized Liver for Study of ...

Application of chimeric mice with humanized liver for ... - PubMed

Application of chimeric mice with humanized liver for study of human-specific drug metabolism · Abstract · MeSH terms · Substances.

Application of chimeric mice with humanized liver for predictive ADME

Thus, chimeric mice with humanized liver would have great advantages in studies on drug metabolism and pharmacokinetics. We have evaluated chimeric mice for ...

Application of Chimeric Mice with Humanized Liver for Study of ...

We evaluated a recently developed chimeric mouse model with humanized liver on uPA/SCID background for its ability to predict human disposition of four model ...

Application of Chimeric Mice with Humanized Liver for Study of ...

Application of Chimeric Mice with Humanized Liver for Study of. Human-Specific Drug Metabolism. Thomas J. Bateman, Vijay G.B. Reddy, Masakazu Kakuni, Yoshio ...

Chimeric mice with humanized liver: Application in drug metabolism ...

The mouse liver cells are mostly replaced with human hepatocytes, which express human drug metabolizing enzymes [10]. Therefore, drug metabolism and PK studies ...

Characterization and applications of chimeric mice with humanized ...

... studies of liver function. Furthermore, we isolated human hepatocytes, called PXB-cells, from the chimeric mice, and provide them for ...

Application of Chimeric Mice with Humanized Liver for Predictive ...

In vitro studies using human liver microsomes can not estimate the induction of drug metabolizing enzymes. Thus, human hepatocytes in primary culture are used ...

Chimeric mice with humanized liver: Application in drug metabolism ...

Chimeric mice with humanized liver contain repopulated human hepatocytes in the majority of the liver, which express human drug-metabolizing enzymes. These mice ...

New applications of chimeric mice with humanized livers

Some years ago, chimeric mice with humanized livers have been introduced as a tool to study human drug metabolism (Strom et al. 2010; Kamimura ...

Humanized liver TK-NOG mice with functional deletion of hepatic ...

Chimeric TK-NOG mice with a humanized liver (normal Hu-liver) are a unique animal model for predicting drug metabolism in humans.

Mice With Human Livers - Gastroenterology

15. Nonetheless, there are many examples of successful use of liver chimeric animals for such studies.16 When careful controls are used in experimental designs ...

Utility of Chimeric Mice with Humanized Liver for Predicting Human ...

The livers of these mice are repopulated mostly with human hepatocytes and express human drug-metabolizing enzymes and drug transporters, suggesting that these ...

Contribution of Humanized Liver Chimeric Mice to the Study of ...

Chimeric mice with humanized livers constitute an attractive emergent experimental model for investigating human metabolism and disposition of drugs.

Humanized Liver Mouse Models for Translational Preclinical Research

PXB-mice are ready to use for supply shipment or study services as early as 12-weeks of age when humanization of the liver meets our criteria. Humanized Liver ...

Chimeric Mouse With Humanized Liver Is an Appropriate Animal ...

In the present study, we provide novel information on the utility of chimeric mice with humanized liver (PXB mice) to evaluate the key events of ...

Utility of Chimeric Mice with Humanized Liver for Predicting Human ...

To solve these issues, the application of humanized mouse models has been considered. For human PK prediction methods, genetically humanized ...

Can 'humanized' mice improve drug development in the 21st century?

Chimeric mice, which have human hepatocytes engrafted in their liver, have been used to study human drug me- tabolism and pharmacodynamic responses for ...

Chimeric Mice With Humanized Livers Demonstrate Human-Specific ...

Chimeric mice with humanized liver (hereafter referred as chimeric mice) may be useful tools for evaluating such human-specific hepatotoxicity ...

Mice With Human Livers - Gastroenterology

The liver plays a central role in many human-specific biological processes and mice with humanized livers can be used to model human metabolism, liver injury, ...

Chimeric mice with humanized liver: Application in drug metabolism ...

... In addition, studies have shown that chimeric mice are good models for human hepatotoxicity. Diseased hepatocytes can also be used and excitingly, iPSC- ...