Application of Mechanistic Pharmacokinetic Model for the ...

A novel colon-targeted MET Delayed-Release (DR) dosage form could be a lucrative option for managing T2DM in renal failure patients.

Conclusion Based on the PBPK modeling, there is a low risk of DDI between anlotinib and potent CYP3A/1A2 inhibitors, but caution and enhanced ...

Application of Semi-Mechanistic Pharmacokinetic and ...

The semi-mechanistic PD model can parameterize the processes of bacterial growth and antibacterial effect and can be integrated with the PK model to simulate ...

Application of machine learning in combination with mechanistic ...

Physiologically based pharmacokinetic modeling ... A whole-body physiologically based pharmacokinetic (PBPK) model was used to simulate the plasma concentration ...

Pharmacokinetic Modeling - an overview | ScienceDirect Topics

Moving from simple, empiric pharmacokinetic models in the 1960s and 1970s, today's models are more mechanistic in nature, incorporating anatomy, physiology, ...

A Mechanistic Pharmacokinetic Model for Liver Transporter ...

However, previous PBPK models under cirrhotic conditions were developed for permeable cytochrome P450 substrates and do not directly apply to ...

Application of Mechanistic Pharmacokinetic–Pharmacodynamic ...

Request PDF | On Nov 19, 2015, Pratap Singh and others published Application of Mechanistic Pharmacokinetic–Pharmacodynamic Modeling toward the Development ...

A mechanistic pharmacokinetic model for intrathecal administration ...

This work presents a distributed mechanistic pharmacokinetic model (DMPK) for predictive analysis of intrathecal drug delivery to CNS.

Mechanistic Pharmacokinetic Modeling for the Prediction of ...

This study illustrates the mechanistic and model-driven application of in vitro uptake and efflux data for human PK prediction for OATP substrates.

Application of mechanistic multiparameter optimization and large ...

Mechanistic modeling approaches based on physiological relevance can be adapted to meet different potential key objectives of the project (e.g. ...

[PDF] Mechanistic Pharmacokinetic Modeling for the Prediction of ...

This study illustrates the mechanistic and model-driven application of in vitro uptake and efflux data for human PK prediction for OATP substrates and shows ...

Development and Application of a Mechanistic Pharmacokinetic ...

To develop a population physiologically-based pharmacokinetic (PBPK) model for simvastatin (SV) and its active metabolite, simvastatin acid (SVA) ...

A mechanistic pharmacokinetic model with drug and antidrug ...

Single-dose pharmacokinetic (PK) studies in healthy subjects have been the design of choice for bioequivalence determination for decades.

Regulatory Utility of Mechanistic Modeling to Support Alternative ...

These mechanistic modeling approaches include physiologically based pharmacokinetic (PBPK) modeling and computational fluid dynamics (CFD) modeling. FDA staff ...

APPLICATIONS OF MECHANISTIC MODELING AND ...

ABSTRACT. Physiologically based pharmacokinetic (PBPK) modeling and simulation techniques have been adopted in the pharmaceutical industry to aid in compound.

A hybrid modeling approach for assessing mechanistic ... - Nature

Pharmacokinetic (PK) predictions of compound disposition are critical for safety and efficacy assessments both before and after drugs enter ...

Evaluation with a semi-mechanistic pharmacokinetic model

A multilevel object-oriented modelling methodology for physiologically-based pharmacokinetics (PBPK): Evaluation with a semi-mechanistic pharmacokinetic model.

Can Mechanistic Static Models for Drug-Drug Interactions Support ...

Mechanistic static and dynamic physiologically based pharmacokinetic models are used in clinical drug development to assess the risk of ...

Integrating PK/PD and Mechanistic Modeling with SimBiology and ...

[PDF] Mechanistic Pharmacokinetic/Target Engagement ...

Mechanistic Pharmacokinetic/Target Engagement/Pharmacodynamic (PK/TE/PD) Modeling in Deciphering Interplay Between a Monoclonal Antibody and Its Soluble Target ...