Application of chimeric mice with humanized liver for predictive ADME

Chimeric mice with humanized liver would have great advantages in studies on drug metabolism and pharmacokinetics.

Application of Chimeric Mice with Humanized Liver for Predictive ...

We have evaluated chimeric mice for studies on absorption, distribution, metabolism, and excretion (ADME). In the liver of the chimeric mice, human phase I and ...

Application of chimeric mice with humanized liver for ... - PubMed

We evaluated a recently developed chimeric mouse model with humanized liver on uPA/SCID background for its ability to predict human disposition of four model ...

Application of Chimeric Mice with Humanized Liver for Predictive ...

Proper and accurate investigations of ADME (absorption, distribution, metabolism, and excretion) of a drug or a candidate are needed to avoid serious adverse ...

Chimeric mice with humanized liver: Application in drug metabolism ...

Here, we review current research on predicting human drug metabolism and PK in drug discovery using chimeric mice with humanized liver. In particular, we ...

New applications of chimeric mice with humanized livers

When human hepatocytes are transplanted into these mice, they repopulate the host liver and may replace up to 95% of the murine hepatocytes. It ...

Application of Chimeric Mice with Humanized Liver for Study of ...

Application of Chimeric Mice with Humanized Liver for Study of Human-Specific Drug Metabolism · Article · Figures & Data · Info & Metrics · eLetters ...

Efficient use of chimeric mice with humanized livers for drug ...

A study on using consecutive experiments to cost-effectively generate predictive ADME using chimeric mice with humanized livers.

Characterization and applications of chimeric mice with humanized ...

We have succeeded in stable mass production of chimeric PXB-mice, whose liver is repopulated by human hepatocytes at a ratio of more than 70%.

Utility of Chimeric Mice with Humanized Liver for Predicting Human ...

The livers of these mice are repopulated mostly with human hepatocytes and express human drug-metabolizing enzymes and drug transporters, ...

Assessment of Chimeric Mice with Humanized Liver as a Tool for ...

Here, we assess the use of chimeric mice with humanized liver as an animal model for the prediction of human metabolism in vivo. Metabolism studies with ...

Utility of Chimeric Mice with Humanized Liver for Predicting Human ...

The livers of these mice are repopulated mostly with human hepatocytes and express human drug-metabolizing enzymes and drug transporters, suggesting that these ...

Using Chimeric Mice with Humanized Livers to Predict ... - AVESİS

Katoh M and Yokoi T (2007) Application of chimeric mice with humanized liver for predictive ADME. Drug Metab Rev 39:145–157. Lamba JK, Lin YS, Schuetz EG ...

Chimeric Mouse with Humanized Liver Consortium Publications

As bile samples are typically not available in human ADME (absorption, distribution, metabolism, and excretion) studies, the proposed approach ...

expression of human phase ii enzymes in chimeric mice with ...

Application of Chimeric Mice with Humanized Liver for Predictive ADME ... Drug metabolism reviews (Softcover ed.) 2007. TLDR.

Humanized liver TK-NOG mice with functional deletion of hepatic ...

Chimeric TK-NOG mice with a humanized liver (normal Hu-liver) are a unique animal model for predicting drug metabolism in humans.

Can 'humanized' mice improve drug development in the 21st century?

(2007) Application of chimeric mice with · humanized liver for predictive ADME. Drug Metab. Rev. 39, 145–157. 13 Suemizu, H. et al. (2008) Establishment of a ...

Chimeric mice with humanized liver: Application in drug metabolism ...

Request PDF | Chimeric mice with humanized liver: Application in drug metabolism and pharmacokinetics studies for drug discovery | Predicting human drug ...

Efficient use of chimeric mice with humanized livers for ... - XenoTech

conducted with the same animals to generate predictive human ADME. 10000. 100000 azo ne. (n g/m. L). Control. TK-NOG Chimeric. Method.

Chimeric mice with humanized liver: tools for the study of drug ...

These mice are called chimeric or "humanized" because the liver is now partially repopulated with human cells. In this report we will review the published work ...