Approaches for Understanding the Mechanisms of Long Noncoding ...

Mammalian genomes encode tens of thousands of long noncoding RNAs (lncRNAs) that have been implicated in a diverse array of biological ...

A more direct way to determine whether a lncRNA acts directly as an RNA molecule is to degrade the mature RNA after it is fully transcribed. There are several ...

Understanding the mechanisms behind long noncoding RNA ...

Long noncoding RNAs (lncRNAs) have been widely recognized for their important roles of gene expression regulation in various biological ...

Approaches for Understanding the Mechanisms of Long Noncoding ...

This includes defining lncRNA function, identifying and characterizing lncRNA-protein interactions, and lncRNA localization in the cell. In this ...

Approaches for Understanding the Mechanisms of Long Noncoding ...

Lan the potential molecular mechanisms of miRNAs, lncRNAs, and circular RNAs in the progression of IDD were described based on the latest literatures, which ...

Long non-coding RNAs: definitions, functions, challenges and ...

We address lncRNA definition, nomenclature, conservation, expression, phenotypic visibility, functional assays and molecular mechanisms ...

Long Non-coding RNAs: Mechanisms, Experimental, and ... - Frontiers

Long Non-coding RNAs: Mechanisms, Experimental, and Computational Approaches in Identification, Characterization, and Their Biomarker Potential in Cancer.

Approaches to probe and perturb long noncoding RNA functions in ...

Third, lncRNAs can operate through a multitude of mechanisms, including chromatin modification, formation of nuclear compartments, transcriptional regulation, ...

Gene regulation by long non-coding RNAs and its biological functions

In this Review, we discuss the mechanisms of lncRNA biogenesis, localization and functions in transcriptional, post-transcriptional and other ...

Long noncoding RNA study: Genome-wide approaches

A better understanding of lncRNAs will open up new vistas in the genomic landscape and shed new light on certain complicated biological mechanisms, providing ...

Computational approaches towards understanding human long non ...

Non-coding RNAs have been one of the major focuses in the field of functional genomics since the last decade. Non-coding RNAs have been largely classified based ...

From structure to function: Route to understanding lncRNA mechanism

Interestingly, long noncoding RNAs (lncRNAs) tend to acquire complex secondary and tertiary structures and their function—in many cases—is ...

Long Non-Coding RNAs: The Regulatory Mechanisms, Research ...

Here, we discuss the recent advances in understanding of the specific regulatory mechanisms of lncRNAs. We focused on the signal, decoy, guide, and scaffold ...

The multidimensional mechanisms of long noncoding RNA function

A major shift in our understanding of genome regulation has emerged recently. It is now apparent that the majority of cellular transcripts ...

Emerging mechanisms of long noncoding RNA function during ...

Long noncoding RNAs (lncRNAs) are increasingly recognized as vital components of gene programs controlling cell differentiation and function.

Roles, Functions, and Mechanisms of Long Non-Coding RNAs in ...

This review summarizes the characteristics of lncRNAs, including their roles, functions, and working mechanisms, describes methods for ...

Mechanisms of long noncoding RNA function in development and ...

LncRNAs are involved in a wide range of cellular mechanisms, from almost all aspects of gene expression to protein translation and stability.

Functional Classification and Experimental Dissection of Long ...

Approaches for Understanding the Mechanisms of Long Noncoding RNA Regulation of Gene Expression. P. McDonelM. Guttman. Biology. Cold Spring Harbor ...

Non-coding RNAs in Development and Disease

There are several types of non-coding linear RNAs such as microRNAs (miRNA) and long non-coding RNAs (lncRNA), as well as circular RNAs (circRNA) consisting of ...

Molecular mechanisms of long noncoding RNAs and their role in ...

Tremendous progress has been made in recent years in understanding the mechanisms of action underlying lncRNAs. LncRNAs not only act as ...