Article Genomic Evolution of Breast Cancer Metastasis and Relapse

Genomic Evolution of Breast Cancer Metastasis and Relapse

Patterns of genomic evolution between primary and metastatic breast cancer have not been studied in large numbers, despite patients with ...

We sequenced whole genomes or a panel of 365 genes on 299 samples from 170 patients with locally relapsed or metastatic breast cancer.

Genomic Evolution of Breast Cancer Metastasis and Relapse.

Patterns of genomic evolution between primary and metastatic breast cancer have not been studied in large numbers, despite patients with metastatic breast ...

Genomic Evolution of Breast Cancer Metastasis and Relapse

Patterns of genomic evolution between primary and metastatic breast cancer have not been studied in large numbers, despite patients with metastatic breast ...

Genomic Evolution of Breast Cancer Metastasis and Relapse

Recurrent breast cancer is almost universally fatal. We characterize 170 patients locally relapsed or distant metastatic cancers using massively ...

Genomic evolution of breast cancer metastasis and relapse | Crick

Patterns of genomic evolution between primary and metastatic breast cancer have not been studied in large numbers, despite patients with ...

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Semantic Scholar extracted view of "Genomic Evolution of Breast Cancer Metastasis and Relapse" by L. Yates et al.

Genomic Evolution of Breast Cancer Metastasis and Relapse

Patterns of genomic evolution between primary and metastatic breast cancer have not been studied in large numbers, despite patients with metastatic breast ...

Genomic Evolution of Breast Cancer Metastasis and Relapse - Lirias

Patterns of genomic evolution between primary and metastatic breast cancer have not been studied in large numbers, despite patients with ...

Genomic evolution of breast cancer metastasis and relapse. - ORA

We sequenced whole genomes or a panel of 365 genes on 299 samples from 170 patients with locally relapsed or metastatic breast cancer. Several ...

Genomic landscape of metastatic breast cancer identifies ... - JCI

However, the majority of metastatic breast cancers do not harbor mutations in these genes, suggesting that others remain to be identified.

Genomic evolution of breast cancer metastasis and relapse

Several lines of analysis indicate that clones seeding metastasis or relapse disseminate late from primary tumors, but continue to acquire mutations, mostly ...

Genomic control of metastasis | British Journal of Cancer - Nature

Comparative genetic studies of primary and metastatic cancers have revealed a complex picture of metastatic evolution with diverse temporal ...

comprehensive genomic profile of primary early breast cancers and ...

All primary and relapse samples harbored at least one genomic alteration, with a median number of six alterations per sample (range 1–16). The ...

Cancer Genome Evolutionary Trajectories in Metastasis - Cell Press

Metastatic cancer is a major cause of death and remains largely incurable. A better understanding of metastasis is therefore desperately ...

The lingering mysteries of metastatic recurrence in breast cancer

In the case of breast cancer, metastatic relapse can occur months to decades after initial diagnosis and treatment. In this review, we provide ...

Genomic Alteration in Metastatic Breast Cancer and Its Treatment

The genomic evolution may result from clonal selection from therapeutic pressure, among other factors. Serial genomic testing may be warranted ...

New Views into the Genetic Landscape of Metastatic Breast Cancer

The study by Yates et al. in this issue of Cancer Cell provides evidence that metastases emerge late during primary breast cancer progression ...

Evolutionary history of metastatic breast cancer reveals minimal ...

Here, we have described the genomic analyses of the primary tumors and metastatic lesions from 99 samples obtained from 20 patients with breast ...

Genomic Evolution of Breast Cancer Metastasis and Relapse. - DKFZ

Patterns of genomic evolution between primary and metastatic breast cancer have not been studied in large numbers, despite patients with metastatic breast ...