Article Small|Molecule Inhibitors of the SOX18 Transcription Factor

Article Small-Molecule Inhibitors of the SOX18 Transcription Factor

SAR for SOX18-DNA Binding Inhibition. Activity data display some clear SAR for SOX18-DNA binding inhibition, with a reduction or elimination of activity by any ...

Small-Molecule Inhibitors of the SOX18 Transcription Factor - PubMed

We identified two compounds, which inspired a series of synthetic SOX18 inhibitors, able to interfere with the SOX18 HMG DNA-binding domain.

Small-Molecule Inhibitors of the SOX18 Transcription Factor

These compounds also perturbed SOX18 transcriptional activity in a cell-based reporter gene system. This approach may prove useful in developing a new class of ...

Small-Molecule Inhibitors of the SOX18 Transcription Factor

Please cite this article as: Fontaine et al., Small-Molecule Inhibitors of the SOX18 Transcription Factor, Cell Chemical Biology (2017), http://dx.doi.org/.

Targeting SOX18 Transcription Factor Activity by Small-Molecule ...

Therefore, our initial hypothesis was that Sm4 inhibition of SOX18 would trigger the expression of SOX17 or SOX7 proteins, leading to the ...

Small-Molecule Inhibitors of the SOX18 Transcription Factor

Home · Organic Compounds · Chemistry · Organic Chemistry · Small Molecules. ArticlePDF Available. Small-Molecule Inhibitors ... SOX18 inhibitors, able to ...

R-propranolol is a small molecule inhibitor of the SOX18 ... - eLife

Identification of the R(+)-propranolol enantiomer as an inhibitor of the SOX18 transcription factor activity breaks open potential of drug ...

Small-molecule inhibitors of the SOX18 transcription factor - UQ ...

Pharmacological modulation of transcription factors (TFs) has only met little success over the past four decades.

Small-Molecule Inhibitors of the SOX18 Transcription Factor

Request PDF | Small-Molecule Inhibitors of the SOX18 Transcription Factor | Pharmacological modulation of transcription factors (TFs) has only met little ...

Small-Molecule Inhibitors of the SOX18 Transcription Factor.

... Mathias Francois. Cell chemical biology. Read more related scholarly scientific articles and abstracts.

Peer review in R-propranolol is a small molecule inhibitor of ... - eLife

Thank you for submitting your article "Propranolol in HLTRS and infantile hemangioma: Stereoselective blockage of the SOX18 transcription factor ...

A transcription factor is the target of propranolol treatment in infantile ...

Fontaine F, et al. Small-molecule inhibitors of the SOX18 transcription factor. Cell Chem Biol. 2017;24(3):346–359. View this article via: ...

Small-Molecule Inhibitors of the SOX18 Transcription Factor - OUCI

Small-Molecule Inhibitors of the SOX18 Transcription Factor ... Authors: Frank Fontaine; Jeroen Overman; Mehdi Moustaqil; Sreeman Mamidyala; Angela Salim; Kamesh ...

Transcription Factor SOX18 Promotes Clear Cell Renal Cell ...

These causal events are the rationale for using angiogenesis inhibitors to treat advanced ccRCC. However, acquired resistance to small-molecule therapeutics ...

Small-Molecule Inhibitors of the SOX18 Transcription Factor - LinkedIn

Pharmacological modulation of transcription factors (TFs) has only met little success over the past four decades.

R-propranolol is a small molecule inhibitor of the SOX18 ...

... Articles; Funding. R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma. Overman J 1 ...

Infantile hemangioma: the common and enigmatic vascular tumor - JCI

Propranolol targets the endothelial transcription factor SOX18 to inhibit vasculogenesis in IH. ... R (+) propranolol inhibits SOX18 by ...

Homodimerization regulates an endothelial specific signature of the ...

Journal Article. Homodimerization regulates an endothelial specific ... et al. Small-Molecule inhibitors of the SOX18 transcription factor .

Small-Molecule Inhibitors of the SOX18 Transcription Factor.

Pharmacological modulation of transcription factors (TFs) has only met little success over the past four decades. This is mostly due to standard drug ...

Publications Alexandrov - Institute for Molecular Bioscience

Journal Article: Small-molecule inhibitors of the SOX18 transcription factor. Fontaine, Frank, Overman, Jeroen, Moustaqil, Mehdi, Mamidyala, Sreeman, Salim, ...