Article Structure of the Regulatory Hyaluronan Binding Domain in ...

Structure of the regulatory hyaluronan binding domain in ... - PubMed

Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44 ... Mol Cell. 2004 Feb 27;13(4):483-96. doi: 10.1016/ ...

Here we show using X-ray crystallography and NMR spectroscopy that these sequences form a lobular extension to the Link module, creating an enlarged HA binding ...

Structure of the Regulatory Hyaluronan Binding Domain in ... - CORE

The pendently) both show that residues 21–169 of human. CD44 (i.e., the N-terminal 149 amino acids of the mature observed differences in the ...

Structure of the regulatory hyaluronan binding domain in the ...

Adhesive interactions involving CD44, the cell surface receptor for hyaluronan, underlie fundamental processes such as inflammatory leukocyte homing and ...

Structure of the regulatory hyaluronan binding domain in the ...

Here we show using X-ray crystallography and NMR spectroscopy that these sequences form a lobular extension to the Link module, creating an enlarged HA binding ...

Structure of the regulatory hyaluronan binding domain in the ...

Here we show using X-ray crystallography and NMR spectroscopy that these sequences form a lobular extension to the Link module, creating an enlarged HA binding ...

Structure of the regulatory hyaluronan binding domain in the ...

Publication type: Article. Publication status: Published. Journal: Molecular Cell. Year: 2004. Volume: 13. Issue: 4. Pages: 483-496. ISSN (print): 1097-2765.

Essential hyaluronan structure for binding with ... - ScienceDirect.com

Hyaluronan specifically binds to aggrecan globular domain 1, which is often referred to as just hyaluronan binding protein (HABP), however, ...

Structure of the regulatory hyaluronan binding domain in the ...

... journal › Article › peer-review. 272 Downloads (Pure). Overview · Fingerprint. Fingerprint. Dive into the research topics of 'Structure of the regulatory ...

Distinctive Properties of the Hyaluronan-binding Domain in the ...

These results reveal that elements additional to the extended Link module are required to stabilize HA binding in Lyve-1 and indicate important structural and ...

(PDF) The structure and regulation of hyaluronan-binding proteins

Home · CD44 Antigens. ArticlePDF AvailableLiterature Review. The structure and regulation of hyaluronan ... hyaluronan-binding ... (s). The HA-binding domain. of.

Hyaluronan-binding Proteins: Tying Up the Giant

Such diversity results in fact from the large number of hyaluronan-binding proteins (often termed hyaladherins) that exhibit significant differences in their ...

Solution Structure of the Link Module: A Hyaluronan-Binding ...

A structural database search revealed close similarity between the Link module and the C-type lectin domain, with the predicted hyaluronan-binding site at an ...

Localization and characterization of the hyaluronan-binding site on ...

Background: The interactions of hyaluronan (HA) with proteins are important in extracellular matrix integrity and leukocyte migration and are usually ...

Hyaluronan-binding Proteins - Journal of Biological Chemistry

The molecular basis of CD44 regulation should become clearer once the tertiary structure of the hyaluronan-binding domain is known, as this ...

Revealing the Mechanisms of Protein Disorder and N ... - Frontiers

The extracellular N-terminal hyaluronan binding domain (HABD) of CD44 is a small globular domain that confers hyaluronan (HA) binding functionality to this ...

Understanding Hyaluronan-Protein Interactions - Glycoforum

The hyaluronan- and aggrecan-binding activities of TSG-6 are pH-dependent; this may result in regulation of its functions via pH gradients that ...

Developmental Regulation of Hyaluronan-Binding Protein (RHAMM ...

Many of the biological activities of HA are mediated through binding to known cellular HA receptors, namely the cell surface glycoprotein CD44 [13] and ...

Mechanical force effect on the two-state equilibrium of the ... - PNAS

Here, we demonstrate that the force applied from the C terminus of the hyaluronan-binding domain of CD44 stabilized the CD44-mediated rolling.

Molecular Dynamics Simulation Study on Allosteric Regulation of ...

The crystal structure of the human CD44 HABD-HA complex has not been determined yet, and there is a lack of the geometry of the HA molecule in ...