Article Tumor and immune reprogramming during immunotherapy in ...

Tumor and immune reprogramming during immunotherapy in ...

Immune checkpoint blockade (ICB) results in durable disease control in a subset of patients with advanced renal cell carcinoma (RCC), ...

Our findings demonstrate that ICB remodels the RCC microenvironment and modifies the interplay between cancer and immune cell populations.

Reprogramming-based gene therapy promotes anti-tumor immunity ...

Cancer immunotherapy induces a tumor antigen-specific T lymphocyte response that kills tumor cells. Dendritic cells, specifically ...

Tumor and immune reprogramming during immunotherapy in ...

Immune checkpoint blockade (ICB) results in durable disease control in a subset of patients with advanced renal cell carcinoma (RCC), but mechanisms driving ...

Tumor and immune reprogramming during immunotherapy in ...

Research output: Contribution to journal › Article › peer-review. 287 Scopus citations. Overview · Fingerprint. Abstract. Immune checkpoint ...

Reprogramming the immunosuppressive tumor microenvironment

A key pathway through which tumors evade the immune system is the reprogramming ... immune microenvironment to facilitate tumor immune evasion and immunotherapy ...

Reprogramming the immunosuppressive tumor microenvironment ...

... tumor immune response, diminishing the efficacy of immunotherapy. ... tumor immune cell functions through tumor metabolic reprogramming in a hostile TME.

Divergent tumor and immune cell reprogramming underlying ...

9 In KEYNOTE-407, while combination of pembrolizumab with chemotherapy achieved greater response rate (57.9%), grade 3 or higher treatment-related adverse event ...

Editorial: Inflammatory Treg reprogramming in the tumor immune ...

Regulatory T (Treg) cells, a subset of immune regulatory cells capable of triggering immunological tolerance, are found within the intricate ...

Reprogramming tumor cells to fight cancer - Science

Dendritic cells (DCs) are important regulators of immunity within the tumor microenvironment (TME). ... during immunotherapy and have serious ...

Reprogramming Turns Cancer Cells into Immune Allies

The reprogramming-meets-immunotherapy modality detailed in the latest report comes from Filipe Pereira, PhD, and his colleagues at Lund ...

Targeted nanomedicine for reprogramming the tumor innate ...

... immune cells to achieve their reprogramming, thus offering promising strategies for cancer immunotherapy. ... within the TME are major ...

Reprogramming the tumor immune microenvironment using ... - Nature

We report a method of targeted immunotherapy using an attenuated Salmonella typhimurium (SAM-FC) engineered to release dual payloads.

Infiltrating treg reprogramming in the tumor immune ...

In “cold” tumors, regulatory T cells (Tregs) and tumor associated macrophages (TAMs) dominate the niche, forming a suppressive TIME through ...

In vivo dendritic cell reprogramming for cancer immunotherapy

In murine immune-competent models, reprogrammed tumor cells recruited and expanded polyclonal cytotoxic and memory T cells within the tumor ...

Tumor Microenvironment Reprogramming Improves Nanomedicine ...

In addition, the combination also altered the polarization of tumor-associated macrophages, favoring the M1 immune-supportive phenotype over the ...

Reprogramming Immune Cells for Enhanced Cancer Immunotherapy

However, with the development of tumors, tumor cells become less immunogenic and lose specific tumor antigens that activate adaptive response at the beginning ...

Dana-Farber research leads to better understanding of the immune ...

The co-authors of “Tumor and immune reprogramming during immunotherapy in advance renal cell carcinoma” are Ziad Bakouny, MD, of Dana-Farber; ...

Reprogramming the Tumor Microenvironment to Improve ...

Innate and adaptive immune cell activities are closely intertwined, both during tumor progression and in response to cytotoxic treatments.

The cancer metabolic reprogramming and immune response

In this article, the ... within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy.