Assessing biological and technological variability in protein levels ...

Protein assays have inherent variability known as technical variation across technical replicates. The statistical metric used to evaluate ...

Assessing biological and technological variability in protein levels measured in pre-diagnostic plasma samples of women with breast cancer.

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Additional file 2: of Assessing biological and technological variability in protein levels measured in pre-diagnostic plasma samples of women with breast ...

Assessing biological and technological variability in protein levels ...

Background Quantitative proteomics allows for the discovery and functional investigation of blood-based pre-diagnostic biomarkers for early cancer detection ...

Comparative proteomics: assessment of biological variability and ...

Quality levels between MS datasets of two samples plays a critical role in relative protein quantitation. When a good quality sample (many ...

Assessing biological and technological variability in protein levels ...

Assessing biological and technological variability in protein levels measured in pre-diagnostic plasma samples of women with breast cancer. https://doi.org ...

Detecting significant changes in protein abundance - ScienceDirect

Although missing values for peptides and proteins due to biological differences are of scientific interests, these missing values can also be a nuisance arising ...

Assessing technical and biological variation in SWATH-MS-based ...

Firstly, differentially expressed proteins were functionally annotated and subjected to pathway analysis (IPA). Metabolic functions dominated ...

Global variability analysis of mRNA and protein concentrations ...

In-depth knowledge of protein concentration variability in single tissue types would enable systems biology to deliver results that better ...

Performance Metrics for Proteomics | NIST

The NCI's Clinical Proteomic Technologies for Cancer (CPTC) have identified technical variability as a major roadblock in the search for protein markers of ...

Assessment of Label-Free Quantification in Discovery Proteomics ...

The intraclass correlation (ICC) is defined in ref 28 as the ratio of intersample to total variance. The statistical analysis was performed ...

Plasma Proteome Profiling to Assess Human Health and Disease

In daily clinical practice, protein levels are generally determined using single-protein immunoassays. High-throughput, quantitative analysis ...

Measurements of heterogeneity in proteomics analysis of ... - Nature

... protein corona applications, including biomarker discovery and assessing the biological fate of nanomedicine technologies. Results ...

Determining Plasma Protein Variation Parameters as a Prerequisite ...

A few attempts have been made to determine the biological and analytical variation of plasma proteins, either individually or together in groups ...

Overview of Protein Assays Methods | Thermo Fisher Scientific - US

Depending on the sample type and purpose for performing an assay, protein-to-protein variation is an important consideration in selecting a protein assay method ...

Quantitative variability of 342 plasma proteins in a human twin ...

We next sought to assess the properties of the SWATH data. First, we calculated the coefficient of variance (CV) of protein level for each protein. Overall, ...

Assessing the Preanalytical Variability of Plasma and Cerebrospinal ...

However, the rate of change for many proteins was relatively consistent; therefore, we were able to characterize biomarkers for detecting sample ...

Unraveling the Intraday Variations in the Tear Fluid Proteome - IOVS

To gauge the consistency of protein levels over time, we computed the CV. Technical variabilities for each protein were computed as outlined in the earlier ...

Mass spectrometry-based proteomics as an emerging tool in clinical ...

Many diseases, including cancer, are regulated at the protein level, making the field of proteomics important. Thus, proteins are of great ...