Assessment of Safety and Efficacy of Combined Trabectedin and ...

The maximum tolerated dose of trabectedin when combined with the specified radiotherapy regimen in phase 1 was 1.5 mg/m 2 , which was the recommended dose used ...

A Nonrandomized Phase 1/2 Clinical Trial - PubMed

Assessment of Safety and Efficacy of Combined Trabectedin and Low-Dose Radiotherapy for Patients With Metastatic Soft-Tissue Sarcomas: A ...

A Nonrandomized Phase 1/2 Clinical Trial - PMC - PubMed Central

Assessment of safety and efficacy of combined trabectedin and low-dose radiotherapy for patients with metastatic soft-tissue sarcomas.

(PDF) Assessment of Safety and Efficacy of Combined Trabectedin ...

In advanced metastatic cases, the combination of trabectedin with low-dose radiation therapy has an excellent remission rate (NCT02275286) [96] ...

Effectiveness and Safety of Trabectedin and Radiotherapy for ...

Aside from the formal assessment of tumor response, we showed here the pattern of activity of the combination. The percentage of complete ...

Efficacy and Safety of Trabectedin or Dacarbazine for Metastatic ...

The final analysis of PFS, performed after 329 PFS events, showed that treatment with trabectedin resulted in a 45% reduction in the risk of ...

Safety and Efficacy of the Combination Lurbinectedin plus ...

While cytotoxic chemotherapy is the standard first-line treatment for patients with metastatic soft-tissue sarcoma (STS), clinical outcomes ...

Efficacy and safety of trabectedin for patients with unresectable and ...

However, the CART analysis revealed that the high-risk group had a combination of tall body height (≥170.3 cm) and young age (<32 years). The ...

Efficacy and safety of nivolumab and trabectedin in pretreated ...

After positive results of a preplanned interim analysis, patients received the combination therapy already starting from Cycle 2 in an “early combination cohort ...

Trabectedin and low-dose radiation therapy in patients with ...

15. Martin-Broto J, Hindi N, Lopez-Pousa A, et al. Assessment of safety and efficacy of combined trabectedin and low-dose radiotherapy ...

A randomized phase III trial comparing trabectedin to best ...

The French Sarcoma Group assessed the efficacy, safety, and quality of life (QoL) of trabectedin versus best supportive care (BSC) in ...

LBA67 TRAMUNE, a phase Ib study combining trabectedin and ...

Primary objective was to assess safety, dose limiting toxicities (DLT), maximum tolerated dose (MTD) and recommended phase II dose of T given on day 1 as 3-hour ...

Trabectedin plus Durvalumab in Patients with Advanced Pretreated ...

This is the first full report of a study investigating the combination of trabectedin with an immune checkpoint inhibitor in solid tumors. In this study of ...

Cardiac safety of trabectedin monotherapy or in combination with ...

Trabectedin is now approved for STS in 80 countries and for ovarian cancer in combination with PLD in 71 countries. European Union (EU) approval ...

Efficacy and safety of trabectedin in metastatic uterine leiomyosarcoma

Additionally, a retrospective analysis of 66 previously-treated unselected patients with metastatic uLMS treated with trabectedin 1.0 mg/m2 to 1.5 mg/m2 ...

A phase I study of combined trabectedin and pegylated liposomal ...

This phase I trial investigated the dosage, safety, pharmacokinetics and efficacy of trabectedin plus pegylated liposomal doxorubicin (PLD) in Japanese patients

Trabectedin Plus Radiotherapy for Advanced Soft-Tissue Sarcoma

Assessment of Safety and Efficacy of. Combined Trabectedin and Low-Dose Radiotherapy for Patients With Metastatic Soft-Tissue Sarcomas: A ...

A phase 3 randomized, open-label, multicenter trial for safety and ...

Highlights · Survival benefit and safety of T + PLD evaluated in third-line setting in platinum-sensitive patients with ROC · Combined T + PLD did not show ...

The Role of Trabectedin in Soft Tissue Sarcoma - Frontiers

Assessment of Safety and Efficacy of Combined Trabectedin and Low-Dose Radiotherapy for Patients with Metastatic Soft-Tissue Sarcomas: A ...

Efficacy and safety of trabectedin or dacarbazine for metastatic ...

In the final analysis of PFS, trabectedin administration resulted in a 45% reduction in the risk of disease progression or death compared with ...