Association of genetic risk and outcomes in patients with atrial ...

Safety events were rare and not different across the PRS-AF and PRS-stroke risk categories, including events related to anti-arrhythmic drug therapy.

Abstract. Aims. The randomized Early Treatment of Atrial Fibrillation for Stroke Prevention Trial found that early rhythm control reduces ...

interactions with early rhythm control in the EAST-AFNET4 trial

Association of genetic risk and outcomes in patients with atrial fibrillation: interactions with early rhythm control in the EAST-AFNET4 trial.

(PDF) Association of genetic risk and outcomes in patients with atrial ...

In a replication analysis, PRS-stroke was associated with incident AF [HR 1.16 (1.14, 1.67), P < 0.001] and with incident heart failure in the UK Biobank [HR ...

Polygenic risk scores in atrial fibrillation: Associations and clinical ...

Polygenic risk scores (PRSs) have become a popular method of quantifying aggregated genetic risk from common risk alleles identified from genome-wide ...

PO-05-197 ASSOCIATION OF GENETIC RISK OF ATRIAL ...

Outcomes of interest included frequency of ventricular tachycardia and in-hospital all-cause mortality. Results: A total of 513,890 patients with a diagnosis of ...

Associations of risk factor burden and genetic predisposition with the ...

Understanding the effects of risk factor burden and genetic predisposition on the long-term risk of atrial fibrillation (AF) is important to ...

Rare and Common Genetic Variation Underlying Atrial Fibrillation Risk

Genetic studies on familial AF have identified associations with several genes, including the ion-channel gene KCNQ1 and the sarcomere gene MYL4 ...

Interaction of genetic risk and lifestyle on the incidence of atrial ...

Results 3094 AF cases occurred during a median follow-up of 12.9 years. Regardless of genetic risk, incidence rates per 1000 person-years were gradually higher ...

Genetic Susceptibility for Atrial Fibrillation in Patients Undergoing ...

Higher AF genetic susceptibility was associated with younger age and fewer clinical risk factors but not recurrence. Arrhythmia recurrence after ...

Atrial fibrillation genetic risk differentiates cardioembolic stroke from ...

Up to this point, our results indicated that AF in ischemic stroke is genetically similar to that discovered in previous genetic studies of AF alone and that ...

Acquired risk factors and incident atrial fibrillation according to age ...

Our results confirmed the existing evidence that early genetic screening could help to increase personalized prevention and control of AF,46 ...

Genetic Predisposition, Clinical Risk Factor Burden, and Lifetime ...

The probability of developing atrial fibrillation (AF) is influenced by both inherited and acquired risk factors. ... Genetic association studies ...

Genetic risk and atrial fibrillation in patients with heart failure

The AF genetic risk score was associated with increased AF prevalence in HFrEF and HFpEF. Genetic variation accounted for 22.9% of overall AF ...

Novel Genetic Markers Associate With Atrial Fibrillation Risk in ...

Fourth, we assumed that the risk of AF associated with each allele is multiplicative and that the effects for each SNP contribute to AF risk additively. Our ...

Interaction of genetic risk and lifestyle on the incidence of atrial ...

8 For comorbidities, we identified all patients with a diagnosis of heart failure, ischaemic stroke, diabetes mellitus, myocardial infarction ...

Genetic risk factors for postoperative atrial fibrillation—a nationwide ...

Both SNPs are downstream variants of PITX2, a gene previously described in association with AF in other patient populations. Similar results were reached in ...

Validation of a genetic risk score for atrial fibrillation - PLOS

Improving the identification of patients with the highest risk for AF to enable appropriate surveillance and treatment, if necessary, is critical to reducing AF ...

Association of Rare Genetic Variants and Early-Onset Atrial ...

It is established that non-White individuals are at a lower risk of developing AF, especially African American and Hispanic/Latinx individuals ...

Genetic risk and atrial fibrillation in patients with heart failure

CONCLUSIONS: The AF genetic risk score was associated with increased AF prevalence in HFrEF and HFpEF. Genetic variation accounted for 22.9% of ...