Astatine|211 81C6|mAb for Brain Tumours

Treatment of Recurrent Brain Tumor Patients with 211At-Labeled ...

Chimeric antitenascin monoclonal antibody 81C6 (ch81C6) (10 mg) was labeled with 71–347 MBq of 211At by use of N-succinimidyl 3-[211At]astatobenzoate. Eighteen ...

Astatine-211 81C6-mAb for Brain Tumours - Open MedScience

Astatine-211 81C6-mAb: A Breakthrough in Brain Tumour Treatment with Alpha Radiation ... Astatine-211 81C6-mAb, a revolutionary radiotherapeutic, uses the ...

Brain intratumoural astatine-211 radiotherapy targeting syndecan-1 ...

In this context, we aimed to develop a locoregional therapy to target tumour burdens and disseminated cells. MAbs represent ideal vectors for ...

treatment of recurrent brain tumor patients with 211At ... - PubMed

... brain tumor patients with 211At-labeled chimeric antitenascin monoclonal antibody 81C6. J Nucl Med. 2008 Jan;49(1):30-8. doi: 10.2967/jnumed.107.046938. Epub ...

At-211-81C6 mAb (Neuradiab) - Oncidium Foundation

... 211At was tested in the intra-cavitary treatment of brain tumors. More than 100 brain tumor patients have already been treated with 131I-labeled murine 81C6 mAb ...

Astatine-211-Labeled MoAB Promising in Brain Cancer Patients

The monoclonal antibody, 81C6, reacts with tenascin, an extracellular matrix glycoprotein that is expressed on more than 95% of brain tumors, ...

Astatine-211 based radionuclide therapy: Current clinical trial ...

... brain tumor patients with 211At-labeled chimeric antitenascin monoclonal antibody 81C6. J Nucl Med. (2008) 49:30–8. doi: 10.2967/jnumed.107.046938. PubMed ...

Tissue distribution and radiation dosimetry of astatine-211-labeled ...

35. J.C. Roeske, G.T.Y. Chen. A dosimetry model for intracavitary radioimmunotherapy of cystic brain tumors. Antibody Immunoconjugates Radiopharm.

Tumor Targeting of 211At-Labeled Antibody under Sodium ...

... 211At: treatment of recurrent brain tumor patients with 211At-labeled chimeric antitenascin monoclonal antibody 81C6. J. Nucl. Med. 2008, 49 ...

Clinical Experience with α-Particle–Emitting 211At: Treatment of ...

... Brain Tumor Patients with 211At-Labeled Chimeric Antitenascin Monoclonal Antibody 81C6. Michael R. Zalutsky, David A. Reardon, Gamal Akabani ...

Realizing Clinical Trials with Astatine-211: The Chemistry ...

In the brain cancer study, performed at Duke University, Durham, North CA, 71–347 MBq 211At-labeled chimeric anti-tenascin monoclonal antibody ...

Targeted radiotherapy of brain tumours | British Journal of Cancer

Astatine-211 labelled chimeric 81C6 clinical trial. An important variable for targeted brain tumour radiotherapy is the nature of the ...

Labeling Monoclonal Antibody with α-emitting 211At at High Activity ...

The authors' own efforts in this regard involved 211At-labeled chimeric 81C6 (ch-81C6), an antitenascin mAb, which was used to treat recurrent brain tumor ...

Astatine-211 radiolabelling chemistry: from basics to advanced ...

... glioma tumours of the tyrosine analogue ... brain tumor patients with 211 At-labeled chimeric antitenascin monoclonal antibody 81C6.

astatobenzylguanidine ([211At]MABG) as an Alpha Particle ...

... brain tumor patients with 211At-labeled chimeric antitenascin monoclonal antibody 81C6 . J Nucl Med. 2008. ;. 49. : 30. –. 8 . Google Scholar · Crossref.

Targeted-Alpha-Therapy Combining Astatine-211 and anti-CD138 ...

... mAb with astatine-211, to destroy the residual cells ... Brain Tumor Patients with 211At-Labeled Chimeric Antitenascin Monoclonal Antibody 81C6.

Tissue distribution and radiation dosimetry of astatine-211-labeled ...

Zalutsky et al. Chimeric anti-tenascin antibody 81C6: Increased tumor localization compared with its murine parent ... brain tumor resection cavities with ...

Particle Emitting 211At: Treatment of Recurrent Brain Tumor Patients ...

Methods: Chimeric antitenascin monoclonal antibody 81C6 (ch81C6) (10 mg) was labeled with 71-347 MBq of (211)At by use of N-succinimidyl 3-[(211)At] ...

Treatment capitalizes on unique qualities of radioisotope to prolong ...

... antibody 81C6, known to seek out and bind specifically to brain cancer cells. ... astatine-211 on other “compartmentalized” cancers, such ...

Astatine-211 Radiotheranostics: A New Era in Cancer Treatment

... cancers, including brain tumours, thyroid cancer, and certain ... By conjugating At-211 to molecules or antibodies that specifically target cancer cells ...