Asthmatic and Normal Respiratory Epithelial Cells Respond ...

The epithelium in asthma is structurally and functionally abnormal, with increased production of mucus, higher permeability, a greater ...

Asthmatic and normal respiratory epithelial cells respond differently ...

Asthmatic and normal respiratory epithelial cells respond differently to mechanical apical stress.

We hypothesized that mature primary bronchial epithelial cells (BECs) cultured in vitro from volunteers with and without asthma would respond ...

Bronchial Epithelium - an overview | ScienceDirect Topics

In asthma it is either disrupted or completely absent with shedding of the columnar cells into the airway lumen. Inflammation is a natural response to tissue ...

American Journal of Respiratory and Critical Care Medicine

American Journal of Respiratory and Critical Care Medicine · Asthmatic and Normal Respiratory Epithelial Cells Respond Differently to Mechanical Apical Stress.

Mechanisms of airway epithelial injury and abnormal repair in ...

In asthma, the inflammatory response precipitates the epithelial injury and drives abnormal basal cell differentiation. This leads to reduced ciliated cells, ...

Putting the Squeeze on Airway Epithelia

Differential Responses to. Compressive Stress in Normal and. Asthmatic Cells. Airway epithelial cells from asthmatic airways have clear differences from those ...

Severe asthma is an epithelial disease - European Respiratory Society

The role played by epithelial cells was revisited in more detail only 15 yrs ago, and their response to inflammation and damage have been clearly found to be ...

Role of airway epithelial cells in development of asthma and allergic ...

Additionally, airway epithelial cells can act as inflammatory promoters capable of directing dendritic cells (DCs) towards a T helper 2 (Th2) response, and as ...

The Dual Role of the Airway Epithelium in Asthma: Active Barrier ...

Among those chronic inflammatory diseases, bronchial asthma is the most common disease of the lung and affects more than 260 million people [1]. It is ...

Remodeling of bronchial epithelium caused by asthmatic ... - Nature

Moreover, HRV infection per se caused transient upregulation of MCM markers and growth factors, followed by low-level virus replication and ...

Genome-wide profiling identifies epithelial cell genes associated ...

Taken together, our findings show that airway epithelial cells in asthma have a distinct activation profile and identify direct and cell-autonomous effects of ...

Diseased Human Bronchial/Tracheal Epithelial Cells – Asthma

Degrees of severity are unique to individual patients as are responses to drug treatments. Adhesion of eosinophils to bronchial epithelial cells, and the ...

Airway epithelial cells in airway inflammation and remodeling in ...

Airway epithelial cells are the front-line barrier to outer world, and abnormal response to environmental agents can cause asthma.

The airway epithelium: an orchestrator of inflammation, a key ...

Facilitated by a disrupted barrier, viral infection activates epithelial cells, triggering innate immune and T2 inflammatory responses, and amplifying the ...

Epithelial cells as regulators of airway inflammation

However, the epithelium also responds to a range of stimuli by producing biologically active mediators that can influence airway inflammation. These include, ...

Airway Remodeling in Asthma - Frontiers

When triggered by allergens, house dust mite or microbes, epithelial cells respond by secreting soluble factors that recruit, and activate immune cells. The ...

Mechanisms and biomarkers of airway epithelial cell damage in ...

Monolayers of AEC from asthmatic children fail to repair post wounding, and these cells produce less fibronectin (FN) than normal children. And ...

Regulation of immune responses by the airway epithelial cell ...

The community of cells lining our airways plays a collaborative role in the preservation of immune homeostasis in the lung and provides ...

The Airway Epithelium—A Central Player in Asthma Pathogenesis

Asthma is a chronic inflammatory airway disease characterized by variable airflow obstruction in response to a wide range of exogenous stimuli.