Attenuation of Antidepressant Effects of Ketamine by Opioid ...

The findings suggest that ketamine's acute antidepressant effect requires opioid system activation. The dissociative effects of ketamine are ...

The findings suggest that ketamine's acute antidepressant effect requires opioid system activation. The dissociative effects of ketamine are not mediated by ...

Attenuation of antidepressant and antisuicidal effects of ketamine by ...

We now present evidence that opioid receptors are necessary for ketamine's acute antisuicidality effect. In ketamine-responsive patients with ...

Attenuation of antidepressant and antisuicidal effects of ketamine by ...

We recently reported that naltrexone blocks antidepressant effects of ketamine in humans, indicating that antidepressant effects of ketamine require opioid ...

Opioid receptor system contributes to the acute and sustained ...

In 2000, a subanesthetic dose (0.5 mg/kg i.v.) of the dissociative anesthetic ketamine was reported to have both rapid and robust antidepressant effects in ...

(PDF) Attenuation of Antidepressant Effects of Ketamine by Opioid ...

Because naltrexone dramatically blocked the antidepressant but not the dissociative effects of ketamine, the trial was halted at the interim analysis.

What ketamine can teach us about the opioid system in depression?

Hence, it appeared that opioid receptors do not participate in either the fast-acting or sustained antidepressant effects of ketamine [Citation ...

Lack of Opioid System in the Antidepressant Actions of Ketamine

Therefore, the present study was undertaken to examine whether naltrexone can block the antidepressant effects of ketamine in chronic social ...

Attenuation of antidepressant and antisuicidal effects of ketamine by ...

Objective: In addition to N-methyl-d-aspartate receptor antagonism, ketamine produces opioid system activation. The objective of this study was ...

Does the Opioid System Block or Enhance the Antidepressant ...

Commentary on: Williams NR, Heifets BD, Blasey C, et al. Attenuation of antagonism effects of ketamine by opioid receptor antagonism.

The endogenous opioid system in the medial prefrontal cortex ...

In preclinical work, systemic naltrexone pretreatment was found to block the antidepressant-like effects of ketamine in three studies [17,18,19] ...

Ketamine activates opioid system to treat depression - ScienceDaily

A new study finds that ketamine's acute antidepressant effect requires opioid system activation, the first time that a receptor site has ...

Bridging rapid and sustained antidepressant effects of ketamine

Ketamine's antidepressant effects are triggered by N-methyl-d-aspartate (NMDA) receptor blockade that impacts intracellular signaling to produce ...

Are NMDA and opioid receptors involved in the antidepressant ...

The rapid-acting antidepressant and antisuicidal effects of the anesthetic (R,S)-ketamine, an N-methyl-d-aspartate receptor (NMDAR) antagonist, ...

Attenuation of antidepressant effects of ketamine by opioid receptor ...

Attenuation of antidepressant effects of ketamine by opioid receptor antagonism: Is it a ketamine-specific effect? ; English · 250-251 · 2 · American Journal of ...

Association of Combined Naltrexone and Ketamine With Depressive ...

Below, we present pilot data that indicate that the antidepressant effects of ketamine are not attenuated by naltrexone pretreatment. As a ...

Opioid System's involvement in Ketamine's Antidepressant-like Effects

In 2000, a subanesthetic dose (0.5 mg/kg i.e.) of the dissociative anesthetic ketamine was reported to have both rapid and robust antidepressant ...

Opioid system is necessary but not sufficient for antidepressive ...

Using behavioral and cellular assays in rodents, we find that blocking opioid function prevents the antidepressant-like effects of ketamine.

Do Ketamine's Antidepressant Actions Reflect Its Opiate Properties?

Because naltrexone greatly attenuated ketamine's antidepressant effects, apparently by presaturating mu and perhaps kappa opiate receptors, ...

Attenuation of antidepressant and antisuicidal effects of ketamine by ...

Attenuation of antidepressant and antisuicidal effects of ketamine by opioid receptor antagonism. Williams NR, Heifets BD, Bentzley BS, Blasey C, Sudheimer ...