Autoactivation of small GTPases by the GEF

Autoactivation of small GTPases by the GEF–effector positive

Autoactivation of small GTPases by the GEF-effector positive ...

Small GTPases are organizers of a plethora of cellular processes. The time and place of their activation are tightly controlled by the ...

[PDF] Autoactivation of small GTPases by the GEF–effector positive ...

The concept of positive autoregulation of small GTPases by the GEF–effector feedback modules is discussed and recent developments in this exciting area of ...

Autoactivation of small GTPases by the GEF–effector positive ...

Here we discuss the concept of positive autoregulation of small GTPases by the GEF–effector feedback modules and survey recent developments in ...

(PDF) Autoactivation of small GTPases by the GEF-effector positive ...

PDF | Small GTPases are organizers of a plethora of cellular processes. The time and place of their activation are tightly controlled by the.

Autoactivation of small GTPases by the GEF–effector positive ... - OUCI

Autoactivation of small GTPases by the GEF–effector positive feedback modules ; Journal: F1000Research, 2019, p. 1676 ; Publisher: F1000 ( Faculty of 1000 Ltd).

Autoactivation of small GTPases by the GEF–effector positive ...

Autoactivation of small GTPases by the GEF–effector positive feedback modules. Andrew Goryachev, Marcin Leda · School of Biological Sciences. Research output ...

Targeting small GTPases: emerging grasps on previously ... - Nature

RalGEF (RalGDS) is another downstream effector of RAS proteins and catalyzes the nucleotide exchange and activates another RAS family member, ...

Regulation of Small GTPases by GEFs, GAPs, and GDIs

76), providing another case for GEF/effector communication. At the cis-Golgi, Arf1 is mainly activated by the ArfGEF GBF1 and recruits the COP1 coatomer ...

Meeting report-Small GTPases in membrane processes - Europe PMC

Autoactivation of small GTPases by the GEF-effector positive feedback modules. Goryachev AB, Leda M · F1000Res, 8:F1000 Faculty Rev-1676, 23 Sep 2019. Cited by ...

Small GTPase - an overview | ScienceDirect Topics

Only in the active GTP-bound state, Ras can interact with downstream effectors. GAPs (GTPase activating proteins) catalyse the return to the inactive GDP-state, ...

Targeting the Small GTPase Superfamily through Their Regulatory ...

This review explores the molecules targeting the GEF, GAP, and GDI GTPase regulatory proteins. It identifies issues in the chemical strategies.

GEFs and GAPs: Critical Elements in the Control of Small G Proteins

Autoactivation of small GTPases by the GEF–effector positive feedback modules · A. GoryachevM. Leda. Biology. F1000Research. 2019. TLDR. The concept of positive ...

Arf GTPase regulation through cascade mechanisms and positive ...

One of these effectors binds in turn the Rab GEF and further stimulates its exchange activity. 2.2. Membrane translocation induces autoinhibition relief. In ...

A non-linear system patterns Rab5 GTPase on the membrane - eLife

GEF/effector coupling and the resulting positive feedback loop of GTPase activation ... (2019) Autoactivation of small gtpases by the gef ...

In vitro reconstitution of small GTPase regulation - Loose - FEBS Press

ARL3 activation requires the co-GEF BART and effector-mediated turnover. ... Autoregulation of Sec7 Arf-GEF activity and localization by positive ...

Structural Insights into the Regulation Mechanism of Small GTPases ...

Several GEF structures are considered auto-inhibited structures because the GTPase binding site is hidden by a domain or motif that flanks the catalytic domain ...

GEF-effector interactions - OUCI

Autoactivation of small GTPases by the GEF–effector positive feedback modules. Andrew B. Goryachev, Marcin Leda. https://doi.org/10.12688/f1000research ...

ARF GTPases and their GEFs and GAPs: concepts and challenges

Characterization of the activation of small GTPases by ... Autoactivation of small GTPases by the GEF–effector positive feedback modules.

ARL3 activation requires the co-GEF BART and effector-mediated ...

As with other GTPases, the activity of ARL proteins is fine-tuned by the action of guanine nucleotide exchange factors (GEFs) and GTPase- ...

A pull-down procedure for the identification of unknown GEFs for ...

(A) General reaction scheme of guanine nucleotide exchange factors for small GTPases. GEFs operate by transiting from a low affinity ternary GTPase:GXP:GEF ...