Axonal degeneration in chemotherapy|induced peripheral ...

Axonal degeneration in chemotherapy-induced peripheral ...

Activation of SARM1 establishes axonal degeneration after nerve injury following a variety of triggers, including neurotoxic chemotherapy. The ...

Axonal degeneration in chemotherapy-induced peripheral ... - PubMed

Multiple pathological mechanisms are involved in the development of chemotherapy-induced peripheral neurotoxicity (CIPN). Recent work has provided insights ...

A Mechanistic Understanding of Axon Degeneration in ... - Frontiers

Chemotherapy-induced peripheral neuropathy (CIPN) is a severe and long lasting side effect caused by diverse anticancer agents that damage sensory and/or motor ...

Axonal degeneration in chemotherapy-induced peripheral ...

Multiple pathological mechanisms are involved in the development of chemotherapy-induced peripheral neurotoxicity (CIPN). Recent work has provided insights into ...

A Mechanistic Understanding of Axon Degeneration in ...

Chemotherapeutic agents cause many short and long term toxic side effects to peripheral nervous system (PNS) that drastically alter quality of life.

Exploring clinical markers of Axon degeneration processes in ...

Chemotherapy-induced peripheral neuropathy is characterized by a dying back axon degeneration [7], in which the most distal nerve endings are ...

Axonal degeneration in chemotherapy-induced peripheral ...

Apigenin Alleviates Allodynia and Hyperalgesia in a Mouse Model of Chemotherapy-Induced Peripheral Neuropathy via Regulating Microglia ...

Pharmacological SARM1 inhibition protects axon structure and ...

Axonal degeneration is an early and ongoing event that causes disability and disease progression in many neurodegenerative disorders of the peripheral and ...

Pathophysiology of Chemotherapy-Induced Peripheral Neuropathy

Similarly, electron microscopy of peripheral nerves from cisplatin-treated patients revealed axonal degeneration of large myelinated fibers as well as secondary ...

Mechanisms of Chemotherapy-Induced Peripheral Neuropathy - MDPI

Figure 3. The mechanisms of CIPN induced by taxanes: Taxanes cause microtubule disruption, which impairs axonal transport and leads to Wallerian degeneration, ...

A Mechanistic Understanding of Axon Degeneration in ...

Axonal degeneration in chemotherapy-induced peripheral neurotoxicity: clinical and experimental evidence · Medicine. Journal of Neurology, Neurosurgery, and…

(PDF) Axonal degeneration in chemotherapy-induced peripheral ...

Multiple pathological mechanisms are involved in the development of chemotherapy-induced peripheral neurotoxicity (CIPN).

Pharmacological bypass of NAD+ salvage pathway protects ... - PNAS

Axon degeneration is caused by multiple chemotherapeutic agents and is a hallmark of chemotherapy-induced peripheral neuropathy (CIPN).

Paclitaxel causes degeneration of both central and peripheral axon ...

Peripheral neuropathy is a common and dose-limiting side effect of many cancer chemotherapies. The taxane agents, including paclitaxel ...

Paclitaxel Reduces Axonal Bclw to Initiate IP3R1-Dependent Axon ...

Many cancer therapies cause axon injury and neurological impairment, resulting in chemotherapy-induced peripheral neuropathy (CIPN). In patients ...

A Comparative Review of Chemotherapy-Induced Peripheral ...

While the underlying mechanisms for CIPN are not known, current data identify a “dying back” axon degeneration of distal nerve endings as the ...

cADPR induced calcium influx mediates axonal degeneration ...

Chemotherapy-induced peripheral neuropathy (CIPN) is a common and often disabling side effect of many traditional chemotherapy drugs.

Targeting Axon Integrity to Prevent Chemotherapy-Induced ...

Chemotherapy-induced peripheral neuropathy (CIPN) is an irreversible off-target adverse effect of many chemotherapeutic agents such as ...

A Mechanistic Understanding of Axon Degeneration in ...

Chemotherapeutic agents cause many short and long term toxic side effects to peripheral nervous system (PNS) that drastically alter quality of life.

Axonal degeneration in chemotherapy-induced peripheral ... - OUCI

Multiple pathological mechanisms are involved in the development of chemotherapy-induced peripheral neurotoxicity (CIPN). Recent work has provided insights ...