B|cell lymphoma 2
BCL2, Bcl-2, PPP1R50, B-cell CLL/lymphoma 2, apoptosis regulator, BCL2 apoptosis regulator, Genes, bcl-2. External IDs, OMIM: 151430; MGI: 88138; HomoloGene ...
B Cell Lymphoma 2: A Potential Therapeutic Target for Cancer ...
This review discusses the role of Bcl-2 in cancer development; it could be exploited as a potential target for developing novel therapeutic strategies.
Definition of B-cell leukemia/lymphoma 2 protein - NCI Dictionary of ...
NCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine.
B-cell lymphoma 2 (Bcl-2) protein family
Bcl-2 is an anti-apoptotic (prosurvival) protein with oncogenic actions. Abnormal expression of Bcl-2 drives the homeostatic balance between cell growth and ...
596 - Gene ResultBCL2 BCL2 apoptosis regulator [ (human)] - NCBI
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes.
Targeting the Bcl-2 Family in B Cell Lymphoma - Frontiers
This review comprehensively examines each member of the Bcl-2 protein family, defining their contribution to B cell lymphomagenesis through mouse models.
Targeting BCL-2 in B-cell malignancies and overcoming therapeutic ...
... B cells to chemotherapeutics. Members of the B-cell leukemia/lymphoma-2 (BCL-2) family of proteins are key regulators of the intrinsic ...
BCL2 (B-Cell Leukemia/Lymphoma 2)
In normal tissue, BCL2 antibodies react with B-cells in the mantle zone, as well as some T-cells. Because BCL2 expression is down-regulated in ...
Types of B-cell Lymphoma - American Cancer Society
Most non-Hodgkin lymphomas (NHL) in the United States are B-cell lymphomas. They include DLBCL, follicular lymphoma, mantel cell lymphoma, ...
BCL2 Gene - GeneCards | BCL2 Protein | BCL2 Antibody
GeneCards Summary for BCL2 Gene. BCL2 (BCL2 Apoptosis Regulator) is a Protein Coding gene. Diseases associated with BCL2 include Follicular ...
B-cell lymphoma 2 family members and sarcomas
Abstract. Targeting the B-cell lymphoma 2 (Bcl-2) family proteins has been the backbone for hematological malignancies with overall survival improvements. The ...
B-Cell Lymphoma 2 (Bcl-2) and Regulation of Apoptosis after ... - MDPI
Background and Objectives: The injury burden after head trauma is exacerbated by secondary sequelae, which leads to further neuronal loss. B-cell lymphoma 2 ...
B-cell lymphoma-2 downregulation is a useful feature supporting a ...
In mature T-cell lymphoproliferations, loss of BCL2 expresssion in T cells can serve as surrogate of neoplastic phenotype.
Treating B-Cell Non-Hodgkin Lymphoma - American Cancer Society
Stage I and most stage II lymphomas. For DLBCL that is only in 1 or 2 lymph node groups on the same side of the diaphragm (the thin muscle that ...
Definition of BCL2 - NCI Dictionary of Cancer Terms
NCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine.
BCL2 Expression in First-Line Diffuse Large B-Cell Lymphoma ...
High reproducibility with 3 different B-cell lymphoma 2 (BCL2) antibodies established assay robustness. •. Interlaboratory reproducibility studies confirmed ...
Targeting BCL-2 in B-cell lymphomas | Blood - ASH Publications
A highly potent and selective oral BCL-2 antagonist, venetoclax, was approved in chronic lymphocytic leukemia, where it has proven to be highly active.
Bcl-2 protein - NordiQC - Immunohistochemical Quality Control
Bcl-2 ("B-cell lymphoma/leukaemia-2"), which acts as an inhibitor of apoptosis, was originally discovered as a proto-oncogene in low-grade B-cell lymphomas.
Definition / general | Pathophysiology | Diagrams / tables | Interpretation | Uses by pathologists | Microscopic (histologic) images | Positive staining - ...
B Cell Lymphoma Protein | Bcl 2 Antigen | BCL2 - Prospec Bio
ProSpec's B-Cell Lymphomas include: Bcl-2 Human (minus BH4 domain), Bcl-2-a Human, BCL-6 Human.
Bcl-2
GeneBcl-2, encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins. BCL2 blocks programmed cell death while other BCL2 family members can either inhibit or induce it.
BCL11A
GeneB-cell lymphoma/leukemia 11A is a protein that in humans is encoded by the BCL11A gene.
Bcl-xL
ProteinB-cell lymphoma-extra large, encoded by the BCL2-like 1 gene, is a transmembrane molecule in the mitochondria. It is a member of the Bcl-2 family of proteins, and acts as an anti-apoptotic protein by preventing the release of mitochondrial contents such as cytochrome c, which leads to caspase activation and ultimately, programmed cell death.