BCL2|Family Dysregulation in B|Cell Malignancies

BCL2-Family Dysregulation in B-Cell Malignancies - PubMed

BCL2-family proteins have a central role in the mitochondrial apoptosis machinery and their expression is known to be deregulated in many ...

BCL2-Family Dysregulation in B-Cell Malignancies - Frontiers

BCL2-family proteins have a central role in the mitochondrial apoptosis machinery and their expression is known to be deregulated in many cancer types.

BCL2-Family Dysregulation in B-Cell Malignancies - PubMed Central

BCL2-family proteins have a central role in the mitochondrial apoptosis machinery and their expression is known to be deregulated in many cancer types.

Targeting BCL-2 in B-cell malignancies and overcoming therapeutic ...

... lymphoma 2 (BCL-2) family of pro- and antiapoptotic proteins. Across B-cell malignancies, apoptosis dysregulation can result from ...

Dysregulation of BCL-2 family proteins in blood neoplasm

However, some patients experience cancer rebound due to venetoclax resistance, as reported in CLL and diffuse large B-cell lymphoma (DLBCL) cases. This is ...

(PDF) BCL2-Family Dysregulation in B-Cell Malignancies

In the present study, we analyzed the expression of the BCL2-family genes across 10 mature B cell malignancies through computational ...

Dysregulation of BCL-2 family proteins by leukemia fusion genes

Gene fusions in ALL. Chromosomal translocations, resulting in the expression of fusion genes, are a hallmark of B-cell malignancies. This likely arises as ...

Targeting the Bcl-2 Family in B Cell Lymphoma - Frontiers

Although lymphoma is a very heterogeneous group of biologically complex malignancies, tumor cells across all B cell lymphoma subtypes share a set of ...

Targeting BCL-2 in B-cell lymphomas | Blood - ASH Publications

Abstract. The B-cell leukemia/lymphoma-2 (BCL-2) family of proteins governs the intrinsic pathway of mitochondrial apoptosis. Dysregulation ...

B-cell lymphoma 2 (Bcl-2) protein family

... dysregulated cell proliferation [6]. Prosurvival Bcl-2 family proteins are therefore tractable drug targets for the development of novel anti-cancer ...

The role of Bcl-2 family members in tumorigenesis - ScienceDirect

BCL-2 immunohistochemical evaluation in B-cell chronic lymphocytic leukemia ... Dysregulation of apoptosis in cancer. J. Clin. Oncol., 17 (1999), p. 2941.

BCL-2 protein family: attractive targets for cancer therapy | Apoptosis

... dysregulation in cancer. We also discuss therapeutic strategies ... Bcl-2 Family in B Cell Lymphoma. Front Oncol 8:636. doi:https://doi ...

Enhancing cell death in B-cell malignancies through targeted ...

The Bcl-3 gene encodes a protein belonging to the IκB family of proteins, which tightly regulates NFκB signaling by acting as an activator or ...

BCL2-Family Dysregulation in B-Cell Malignancies - OUCI

BCL2-Family Dysregulation in B-Cell Malignancies: From Gene Expression Regulation to a Targeted Therapy Biomarker · Benoît Tessoulin · Antonin Papin · Patricia ...

B-cell lymphoma 2 family members and sarcomas

Targeting the B-cell lymphoma 2 (Bcl-2) family proteins has been the backbone for hematological malignancies with overall survival improvements.

BCL2 (B-Cell Leukemia/Lymphoma 2)

Therefore, dysregulation of BCL2 family has a major role in tumor formation. The BCL2 family is also involved in other diseases, such as ...

The rise of apoptosis: targeting apoptosis in hematologic malignancies

Abstract. Dysregulation of the B-cell leukemia/lymphoma-2 (BCL-2) family of proteins of the intrinsic apoptotic pathway is fundamental to the pathophysiolo.

[PDF] Targeting BCL-2 in B-cell lymphomas. | Semantic Scholar

BCL2-Family Dysregulation in B-Cell Malignancies: From Gene Expression Regulation to a Targeted Therapy Biomarker · B. TessoulinA. Papin +4 authors. D. Chiron.

Bcl-2 family proteins in breast development and cancer - Oncotarget

Furthermore, sustained Bcl-2 family dysregulation contributes to evasion of cell death, a hallmark of cancer. ... B breast cancers [54] and ...

Altmetric – BCL2-Family Dysregulation in B-Cell Malignancies

BCL2-Family Dysregulation in B-Cell Malignancies: From Gene Expression Regulation to a Targeted Therapy Biomarker. Published in.