BRD4 Degradation Enhanced Glioma Sensitivity to Temozolomide ...

Temozolomide (TMZ), as a clinical first-line chemotherapeutic agent for gliomas, is capable of inducing DNA damages of glioma cells to further ...

(PDF) BRD4 Degradation Enhanced Glioma Sensitivity to ...

ArticlePDF Available. BRD4 Degradation Enhanced Glioma Sensitivity to Temozolomide by Regulating Notch1 via Glu‐Modified GSH‐Responsive Nanoparticles. Wiley.

BRD4: New hope in the battle against glioblastoma - ScienceDirect

Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles. ... sensitive versus -resistant ...

BRD4: An emerging prospective therapeutic target in glioma - PMC

... BRD4 inhibitors restores sensitivity ... Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles.

BET protein inhibition sensitizes glioblastoma cells to temozolomide ...

BETi-mediated attenuation of MGMT expression was associated with reduction of BRD4- and Pol II-binding at the MGMT promoter. On the functional ...

An inhibitor of BRD4, GNE987, inhibits the growth of glioblastoma ...

... BRD4 degradation via VHL-mediated proteasomal degradation, which ... FTO inhibition enhances the antitumor effect of temozolomide by ...

BRD4: An emerging prospective therapeutic target in glioma

ness to BBIs by degrading ... Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy · for gliomas using targeted ...

Bivalent activity of super-enhancer RNA LINC02454 controls 3D ...

Glioma cell sensitivity to temozolomide (TMZ) is critical for effective treatment and correlates with patient survival, although mechanisms ...

MZ1, a BRD4 inhibitor, exerted its anti-cancer effects by suppressing ...

... glioblastoma: chemoresistance to temozolomide. Neurol Med Chir ... BRD4 promotes glioma cell stemness via enhancing miR-142-5p-mediated ...

A Review of Approaches to Potentiate the Activity of Temozolomide ...

... Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles. ... degradation; Enhanced brain and tumor ...

Nanomedicine-based combination therapies for overcoming ...

Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles. ... sensitivity of TMZ ...

Current advances in temozolomide encapsulation for ... - Theranostics

Glioblastoma is the most common and lethal brain tumor in adults. The incorporation of temozolomide (TMZ) into the standard treatment has increased the ...

A Potential Mechanism of Temozolomide Resistance in Glioma ...

However, suppressing the SLC7A11 expression can enhance the sensitivity of gliomas to TMZ using siRNA (46). ... degradation of Nrf2 by ...

BRD4: An emerging prospective therapeutic target in glioma - OUCI

Miller, Isocitrate dehydrogenase-mutant glioma: Evolving clinical and therapeutic implications, Cancer, № 123, с. · Zang, Potential epigenetic-based therapeutic ...

Advanced Science - Wiley Online Library

BRD4 Degradation Enhanced Glioma Sensitivity to Temozolomide by Regulating Notch1 via Glu-Modified GSH-. In this study, a Glu-modified and GSH-responsive ...

Glioblastoma: Current Status, Emerging Targets, and Recent ...

Moreover, IDH inactivation promotes the sensitivity of tumor cell to both senescence induced by radiation and erlotinib, increasing the survival ...

BRD4: An Emerging Prospective Therapeutic Target in Glioma

... Enhanced efficacy of. 644. combined temozolomide and bromodomain inhibitor therapy for gliomas using. 645 ... To enhance GSCs sensitivity to HDAC3i, we ...

Sml1175 | Sigma-Aldrich

FK228 augmented temozolomide sensitivity in human glioma cells by blocking PI3K/AKT/mTOR signal pathways. YiHan Wu et al. Biomedicine & pharmacotherapy ...

A BRD4 PROTAC nanodrug for glioma therapy via the intervention ...

nanosystem (SPP-ARV-825) is constructed by incorporating the BRD4-degrading ... temozolomide (12 d) ... Enhanced Nanoparticle Delivery to Solid Tumors.

Anticancer Effects of I-BET151, an Inhibitor of Bromodomain and ...

... different combination types that substantially increase the sensitivity of select chemotherapy drugs and achieve an improved therapeutic efficacy.