Bcl|2 family proteins as targets for cancer therapy

Bcl-2 family proteins as targets for cancer therapy - PubMed

Cell death by apoptosis and permanent cell cycle arrest by senescence serve as barriers to the development of cancer.

BCL-2 protein family: attractive targets for cancer therapy - PubMed

Acquired resistance to cell death is a hallmark of cancer. The BCL-2 protein family members play important roles in controlling apoptotic cell death.

Bcl-2 family proteins as targets for cancer therapy - ScienceDirect

The anti-apoptotic Bcl-2 family proteins not only protect against cell death by apoptosis, but they also allow senescent cells to survive.

BCL-2 protein family: attractive targets for cancer therapy | Apoptosis

This review describes the roles of the various pro-survival and pro-apoptotic members of the BCL-2 protein family in normal development and organismal function.

The role of BCL-2 family proteins in regulating apoptosis and cancer ...

Consequently, overcoming the resistance of tumor cells to apoptosis by inhibiting the BCL-2 anti-apoptotic protein is a novel therapeutic regimen based on tumor ...

Bcl-2 family inhibitors sensitize human cancer models to therapy

BH3 mimetics, targeting the Bcl-2 family anti-apoptotic proteins, represent a promising therapeutic opportunity in cancers.

Exploring BCL-2 Inhibitors in Cancer Therapy

Consequently, these proteins have emerged as promising targets for therapeutic interventions. The BCL-2 protein family is central to apoptosis and plays a ...

Targeting BCL-2 family proteins using BH3 mimetic drugs for cancer ...

This systematic review of clinical trials investigates the efficacy and clinical relevance of BCL-2 family protein inhibitors in managing malignancies.

Targeting Anti-Apoptotic BCL-2 Family Proteins for Cancer Treatment

Several anti-apoptotic members including BCL-2, BCL-X L , and MCL-1 are well-validated anticancer targets.

The BCL-2 protein family, BH3-mimetics and cancer therapy - Nature

Interestingly, loss of the transcription factor ASCIZ, with consequent reduction in its target dynein light chain 1, which reportedly links BIM ...

Targeting BCL-2 regulated apoptosis in cancer | Open Biology

The ability of a cell to undergo mitochondrial apoptosis is governed by pro- and anti-apoptotic members of the BCL-2 protein family.

Bcl-2 family proteins in breast development and cancer - Oncotarget

These studies suggest that targeting Bcl-2 family proteins in combination with current chemotherapies and targeted therapies may increase tumor ...

B Cell Lymphoma 2: A Potential Therapeutic Target for Cancer ...

p53 regulates Bcl-2 family proteins and hence controls mitochondria-mediated apoptosis [17]. p53 is a controller of the expression of the Bcl-2 gene. It ...

B-cell lymphoma 2 (Bcl-2) protein family

Prosurvival Bcl-2 family proteins are therefore tractable drug targets for the development of novel anti-cancer therapies, as well as immunotherapies. Small ...

BCL-2 Family Proteins: Critical Checkpoints of Apoptotic Cell Death

The BCL-2 family of proteins constitutes a critical control point in apoptosis residing immediately upstream of irreversible cellular damage, ...

BCL2-Family Dysregulation in B-Cell Malignancies - Frontiers

BCL2-family proteins have a central role in the mitochondrial apoptosis machinery and their expression is known to be deregulated in many cancer types.

Antiapoptotic Bcl-2 protein as a potential target for cancer therapy

The family of Bcl-2 proteins contains two classes of proteins, proapoptotic and antiapoptotic. Death or survival of the cell depends on the balance between ...

The involvement of Bcl-2 family proteins in AKT-regulated cell ...

The combination of cisplatin and Bcl-2 family protein inhibitor could be a strategy for the treatment of cisplatin-resistant ovarian cancer.

Small Molecule Inhibitors of Bcl-2 Family Proteins for Pancreatic ...

Bcl-2 family member proteins are anti-apoptotic molecules that are known to be overexpressed in most cancers including PC. The anti-apoptotic machinery has been ...

(PDF) BCL-2 protein family: attractive targets for cancer therapy

Defects in apoptosis can promote tumorigenesis and ... [Show full abstract] render malignant cells refractory to anticancer therapeutics.