Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist ...

We have evaluated the effect of a 6-month treatment of APPsw/PS1dE9 mice with the potent and selective A 2A R antagonist MSX-3 from 3 to 9-10 months of age.

Consumption of caffeine, a non-selective adenosine A2A receptor (A2AR) antagonist, reduces the risk of developing Alzheimer's disease (AD) and mitigates ...

Beneficial Effect of a Selective Adenosine A 2A Receptor Antagonist ...

While short-term treatment with A2AR antagonists have been shown to alleviate cognitive deficits in mouse models of amyloidogenesis, impact of a ...

Can adenosine A2A receptor antagonists modify motor behavior ...

Adenosine A2A receptors are one potential non-dopaminergic target as they are selectively localized to the basal ganglia and to the indirect output pathway ...

Adenosine A2A receptor antagonists: from caffeine to selective non ...

Adenosine receptor agonists display benefit in animal models of inflammatory and ischaemic conditions, and agonists of A2A receptors, such as ...

Adenosine A2A receptor antagonist - Wikipedia

Adenosine A2A receptor antagonists are a class of drugs that blocks adenosine at the adenosine A2A receptor. Notable adenosine A2A receptor antagonists ...

Antidepressant effects of selective adenosine receptor antagonists ...

The obtained results showed that DPCPX and istradefylline administered jointly with NMDA receptor ligands (except for DPCPX + D–cycloserine ...

Can adenosine A2A receptor antagonists be used to treat cognitive ...

Targeting adenosine A 2A receptors may address some of the neuropsychiatric components of non-motor symptoms – notably cognitive impairment, depression and ...

Adenosine A2A receptor antagonist treatment of Parkinson's disease

Background: Observations in animal models suggest that A2A antagonists confer benefit by modulating dopaminergic effects on the striatal dysfunction ...

Dual roles of the adenosine A2a receptor in autoimmune ...

A2aR activation was shown to confer beneficial anti-inflammatory effects in models of ischemic or traumatic tissue damage in different organ ...

The Pharmacological Potential of Adenosine A2A Receptor ... - MDPI

This is particularly true of the potential use of centrally acting adenosine A2A receptor antagonists for the treatment of neurological and psychiatric ...

The Interaction of Selective A1 and A2A Adenosine Receptor ... - MDPI

Instead, the A2A receptor is coupled to Gs protein and enhances the adenylate cyclase activity. This subtype of adenosine receptors is mostly localized in the ...

International Union of Basic and Clinical Pharmacology. CXII

Significance Statement Adenosine receptors (ARs) are of continuing interest for future treatment of chronic and acute disease conditions, ...

Ligand-Activation of the Adenosine A2a Receptors Inhibits IL-12 ...

Abstract. Adenosine (ADO) exerts potent anti-inflammatory and immunosuppressive effects. In this paper we address the possibility that these effects are pa.

Crystal structure of adenosine A2A receptor in complex with clinical ...

For example, the A2AAR antagonist Istradefylline has been approved in Japan and the USA for the treatment of Parkinson's Disease. Preclinical ...

Pharmacological Characterization of a Novel, Potent Adenosine A1 ...

It is demonstrated that the novel, selective, and orally active dual adenosine A1 and A2A receptors antagonist ASP5854 improves motor impairments, ...

Historical and Current Adenosine Receptor Agonists in Preclinical ...

NNC-21-0136 15 is an A1AR selective agonist that was designed for neuroprotection. Its hemodynamic effects were minimal, revealing a brain-protective effect in ...

ST 1535: a preferential A2A adenosine receptor antagonist

The beneficial effect of ST 1535 in improving ... Antiparkinson effect of a new selective adenosine. A2A receptor antagonist in MPTP-treated ...

Caffeine and a selective adenosine A2A receptor antagonist induce ...

These data indicate that striatal dopaminergic pathways play an important role in mediating the locomotor sensitization and reward effects after ...

Beneficial effect of a selective adenosine A2A receptor antagonist in ...

Consumption of caffeine, a non-selective adenosine A2A receptor (A2AR) antagonist, reduces the risk of developing Alzheimer's disease (AD) and mitigates both ...