Beta Cell Dysfunction and Insulin Resistance

Beta Cell Dysfunction and Insulin Resistance - PMC - PubMed Central

As beta cell dysfunction and insulin resistance exacerbate, hyperglycemia amplifies leading to the progression to type 2 diabetes (Figure 1). This review ...

Beta cell dysfunction and insulin resistance - PubMed

Beta cell dysfunction and insulin resistance are inherently complex with their interrelation for triggering the pathogenesis of diabetes ...

Pancreatic Beta-cell Dysfunction in Type 2 Diabetes - Sage Journals

Although diabetes begins with insulin resistance, β-cell dysfunction (decline of β ... Beta cell dysfunction and insulin resistance. Front ...

Five Stages of Evolving Beta-Cell Dysfunction During Progression to ...

Section I: Insulin Resistance-Beta-Cell Connection in Type 2 Diabetes ... Five Stages of Evolving Beta-Cell Dysfunction During Progression to ...

β Cell dysfunction during progression of metabolic syndrome to ... - JCI

β Cell compensation and dysfunction in MetS and T2DM. A lifestyle of overnutrition and/or inactivity can give rise to an insulin-resistant ...

Beta Cell Dysfunction in Youth- and Adult-Onset Type 2 Diabetes

Clinical Evidence of the β-Cell Dysfunction Role in T2D. Several epidemiological studies in adult populations have shown that β-cell malfunction is a sine qua ...

Early beta cell dysfunction vs insulin hypersecretion as the primary ...

Four decades ago, many felt insulin resistance was the primary abnormality in type 2 diabetes, with beta cell dysfunction being a later ...

Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 ...

In individuals with type 2 diabetes, function within the sustained β cell volume further declines. These results indicate that dysfunction of ...

β-cell secretory dysfunction: a key cause of type 2 diabetes

Correspondence. β-cell secretory dysfunction: a key cause of type 2 diabetes – Authors' reply. Weir et al. The Lancet Diabetes & EndocrinologyMay, 2020.

β-Cell function or insulin resistance was associated with the risk of ...

Postpartum β-cell dysfunction, insulin resistance (IR) and obesity are all associated with postpartum type 2 diabetes. However, very few studies have examined ...

Insulin Resistance and β-Cell Dysfunction in Relation to ...

Insulin resistance (IR) and β-cell dysfunction are two major features in the pathogenesis of type 2 diabetes (3, 4). Both pathological states synergistically ...

Contributions of β-Cell Dysfunction and Insulin Resistance to the ...

Contributions of β-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose.

Human Physiology of Genetic Defects Causing Beta-cell Dysfunction

A natural increase in insulin resistance during pregnancy could provide a powerful setup for physiological studies on variants affecting beta-cell dysfunction, ...

Insulin resistance versus β-cell dysfunction in type 2 diabetes

Indeed, clarification of these relationships between insulin resistance and β-cell dysfunction on an individual level is important given the ...

Full article: Beta-cell failure in type 2 diabetes: mechanisms, markers ...

Therapies that rely on beta-cell function to stimulate insulin secretion may have reduced effectiveness in people with progressive beta-cell dysfunction and ...

Roles of insulin resistance and beta-cell dysfunction in ... - JCI

The roles of insulin resistance and beta-cell dysfunction in glucocorticoid-induced diabetes were determined in Wistar and Zucker (fa/fa) rats.

β-cell dysfunction and insulin resistance in type 2 diabetes

β-Cell dysfunction resulting from glucose toxicity and lipotoxicity is potentially reversible with restoration of metabolic control. Therefore, attention to ...

Beta Cell Dysfunction and Insulin Resistance - Semantic Scholar

Beta cell dysfunction supersedes insulin resistance in inducing diabetes and both pathological states influence each other and presumably synergistically ...

(PDF) Beta Cell Dysfunction and Insulin Resistance - ResearchGate

Beta cell dysfunction results from inadequate glucose sensing to stimulate insulin secretion therefore elevated glucose concentrations prevail.

The evolution of β‐cell dysfunction and insulin resistance in type 2 ...

Insulin resistance and β-cell dysfunction have important roles in the pathogenesis and evolution of type 2 diabetes.