Beyond the unfolded protein response

PERK, Beyond an Unfolded Protein Response Sensor in Estrogen ...

We address the mechanistic progress on how PERK acts as a multifunctional molecule to commit E 2 to inducing apoptosis in endocrine-resistant breast cancer.

PERK, Beyond an Unfolded Protein Response Sensor in Estrogen ...

PERK activates apoptotic cascades in multiple ways. Apoptosis is ultimately induced by sustained PERK activation after E2 therapy in endocrine-resistant breast ...

The unfolded protein response: controlling cell fate decisions under ...

Activation of UPR stress sensors. How protein-folding stress at the ER is sensed has been a central topic in the field for the past 10 years.

Mechanisms, regulation and functions of the unfolded protein ...

Recently, it has become evident that the UPR has essential cell functions beyond ER proteostasis, and therefore we discuss how the UPR controls ...

Beyond the cell factory: Homeostatic regulation of and by the UPR ER

We focus on recent findings and emerging themes in additional roles of the UPR ER outside of protein homeostasis, including lipid homeostasis, autophagy, ...

The Unfolded Protein Response and Cell Fate Control - ScienceDirect

Genetic and pharmacological inhibition of PERK or IRE1 signaling demonstrated their essential activity in driving tumor growth. Beyond providing ...

Disclosing the role of XBP1s in Alzheimer's disease - Cell Press

Beyond the unfolded protein response: Disclosing the role of XBP1s in Alzheimer's disease ... XBP1 is a master regulator of the unfolded protein ...

Unfolded protein response - Wikipedia

The unfolded protein response (UPR) is a cellular stress response related to the endoplasmic reticulum (ER) stress. It has been found to be conserved ...

The Unfolded Protein Response and Cell Fate Control

When misfolded proteins accumulate above a critical threshold, this sets in motion a signal transduction pathway called the unfolded protein response (UPR) ...

The Unfolded Protein Response and Cell Fate Control

Genetic and pharmacological inhibition of PERK or IRE1 signaling demonstrated their essential activity in driving tumor growth. Beyond providing ...

The Mitochondrial Unfolded Protein Response as a Non-Oncogene ...

The Mitochondrial Unfolded Protein Response as a Non-Oncogene Addiction to Support Adaptation to Stress during Transformation in Cancer and Beyond. \r\nTimothy ...

Emerging Roles for the Unfolded Protein Response in the ...

Beyond its protective role, it plays important functions during normal development in response to elevated demand for protein folding. Several UPR effectors ...

controlling cell fate decisions under ER stress and beyond - UFRGS

The unfolded protein response (UPR) stress sensors, inositol-requiring protein 1α (IRE1α), protein kinase RNA-like endoplasmic reticulum (ER) ...

The IRE1α pathway in glomerular diseases: The unfolded protein ...

ER protein misfolding causes ER stress and activates a compensatory signaling network called the unfolded protein response (UPR). Disruption of the UPR, in ...

controlling cell fate decisions under ER stress and beyond - Ex Libris

; The unfolded protein response: controlling cell fate decisions under ER stress and beyond. ; Hetz, Claudio ;. ; Nature reviews. Molecular cell biology, 2012 ...

controlling cell fate decisions under ER stress and beyond - New ...

; The unfolded protein response: controlling cell fate decisions under ER stress and beyond. ; Hetz, Claudio ;. ; Nature reviews. Molecular cell biology, 2012 ...

The unfolded protein response: integrating stress signals through ...

An overview of the signaling and regulatory mechanisms underlying IRE1α function is provided and the emerging role of the UPR in adaptation to protein ...

Unfolded protein response - GeneGlobe - QIAGEN

ER stress activates a signaling network called the Unfolded Protein Response (UPR) to alleviate this stress and restore ER homeostasis, promoting cell survival ...

Controlling cell fate decisions under ER stress and beyond

ER stress is buffered by the activation of the unfolded protein response (UPR), a homeostatic signalling network that orchestrates the recovery of ER function, ...

controlling cell fate decisions under ER stress and beyond

... (UPR), an adaptive reaction that reduces unfolded protein load ... The unfolded protein response: controlling cell fate decisions under ER stress and beyond ...