Biological Role and Therapeutic Potential of IDH Mutations in Cancer

Hotspot mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) occur in a variety of myeloid malignancies and ...

Biological role and therapeutic potential of IDH mutations in cancer

Hotspot mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) occur in a variety of myeloid malignancies and solid tumors.

Biological Roles and Therapeutic Applications of IDH2 Mutations in ...

IDH2 Mutations in Human Cancer. IDH mutations have been detected in multiple tumor types, including various solid tumors and several myeloid malignancies. High ...

Biological Role and Therapeutic Potential of IDH Mutations in Cancer

... IDH1 and IDH2 mutations are common in tumors and they are usually regarded as having similar functions in tumorigenesis and development. 3 For many ...

IDH mutation in glioma: molecular mechanisms and potential ...

... carcinoma. A series of seminal studies further elucidated the biological impact of the IDH mutation and uncovered the potential role of IDH ...

Biological Role and Therapeutic Potential of IDH Mutations in Cancer

Biological Role and Therapeutic Potential of IDH Mutations in Cancer. Matthew S. Waitkus, Bill H. Diplas, Hai Yan. Cancer Cell. Volume 34 Issue 2 Pages 186-195 ...

IDH mutations in cancer and progress toward development of ...

Inhibition of mutant IDH shows promise as a treatment approach in hematologic malignancies, with further development ongoing in solid tumors and glioma. The ...

Fundamental Research Paved the Way for the Development of ...

Prior cancer biology research funded by DCB showed that mutant IDH reduces the infiltration of immune cells to the tumor and that the IDH ...

Mutant IDH in Gliomas: Role in Cancer and Treatment Options - MDPI

It is well recognised that IDH mutations have a biological impact both intracellularly and as part of the tumour microenvironment, favouring tumour formation ...

Cancer-associated mutation and beyond: The emerging biology of ...

Cancer-associated mutations in IDH1 and IDH2 represent one of the most comprehensively studied mechanisms of IDH pathogenic effect. Mutant enzymes produce (R)-2 ...

IDH mutations in cancer and progress toward development of ...

Inhibition of mutant IDH shows promise as a treatment approach in hematologic malignancies, with further development ongoing in solid tumors and glioma. The ...

Comprehending and Exploiting IDH Gene Mutations in Gliomas

IDH1 and IDH2 mutations are restricted to specific arginine residues in the active site of the enzymes and are gain-of-function, i.e. they confer a neomorphic ...

Biological Roles and Therapeutic Applications of IDH2 Mutations in ...

Isocitrate dehydrogenase (IDH) is a key metabolic enzyme catalyzing the interconversion of isocitrate to α-ketoglutarate (α-KG). Mutations in IDH lead to ...

Therapeutic inhibition of isocitrate dehydrogenase mutations in ...

Methods: Here, we provide an overview of the IDH mutation role and discuss its role in tumorigenesis and progression of some solid cancers, in which the ...

PARP Inhibitors for Cancers with IDH Mutations - NCI

Now the NCI and Yale research groups have shown that certain mutations in the IDH genes may present the same therapeutic opportunity in gliomas, ...

the effective strategies for therapy of IDH-mutated cancers

Mitochondrial glutaminase (GLS) is often in charge of translating glutamine into glutamate and serving as a key role in cell metabolism, growth, ...

Differential isocitrate dehydrogenase 1 and ... - Oxford Academic

Targeted therapy related to isocitrate dehydrogenase (IDH) is an extremely important treatment. IDH1 and IDH2 mutations are generally thought to ...

Oncogenic Isocitrate Dehydrogenase Mutations: Mechanisms ...

Even though the incidence of these diseases is rare, and IDH mutations are relevant in only a small proportion of each patient population, there is much to be ...

Targeting Isocitrate Dehydrogenase (IDH) in Solid Tumors - MDPI

These mutations lead to neomorphic enzymatic activity affecting cancer pathogenesis. This review aims to summarize the diagnostic and prognostic role of IDH ...

IDH mutation and cancer stem cell | Essays in Biochemistry

CSCs are closely related to the critical hallmarks in human cancers, ranging from oncogenesis to disease progression, therapeutic resistance, and overall ...