Biologically Informed Neural Networks Predict Drug Responses

In this issue, Kuenzi et al. model the sensitivity of cancers to drugs using deep neural networks with a hierarchical structure derived from the Gene Ontology.

Biologically Informed Neural. Networks Predict Drug Responses. Casey S. Greene1,2,* and James C. Costello3. 1Department of Systems Pharmacology and ...

MOViDA: multiomics visible drug activity prediction with a ...

We have engineered an artificial neural network model designed specifically for predicting drug sensitivity. This model utilizes a biologically informed ...

A systematic review of biologically-informed deep learning models ...

[93] proposed a pathway-guided deep neural network (DNN) framework to predict drug sensitivity in cancer cells, using known biological signaling ...

Biologically Informed Neural Networks Predict Drug Responses

Request PDF | Biologically Informed Neural Networks Predict Drug Responses | Deep neural networks often achieve high predictive accuracy on biological ...

Interpreting biologically informed neural networks for enhanced ...

Our approach integrates a priori knowledge of the relationships between proteins and biological pathways and biological processes into sparse ...

Optimal fusion of genotype and drug embeddings in predicting ...

In DrugCell, a 'late fusion' approach is used, where the final-stage representations of genes and drugs are combined and inputted into a network ...

Biologically Informed Neural Networks Predict Drug Responses.

Deep neural networks often achieve high predictive accuracy on biological problems, but it can be hard to contextualize how and explain why ...

Systems biology informed neural networks (SBINN) predict ... - Nature

Using this approach, we determine biomarkers of patient response and identify potential mechanisms of drug resistance. We develop systems ...

BioXNet: a biologically inspired neural network for deciphering anti ...

BioXNet exhibited superior performance in drug response prediction tasks in both preclinical and clinical settings. An analysis of BioXNet's ...

XMR: an explainable multimodal neural network for drug response ...

Introduction: Existing large-scale preclinical cancer drug response databases provide us with a great opportunity to identify and predict ...

Explainable drug side effect prediction via biologically informed ...

In-vitro or in-vivo approach to detect potential SEs is not scalable for many drug candidates during the preclinical stage. Recent advances in ...

MMDRP: drug response prediction and biomarker discovery using ...

A direct comparison with other deep learning-based predictive models was not possible, as they are trained to predict IC50 rather than MAE. Our experiments have ...

Predicting Drug Response and Synergy Using a Deep Learning ...

Biologically Informed Neural Networks Predict Drug Responses. Cancer Cell, Volume , Issue , November , Pages -. Casey S. Greene, James C ...

BioXNet: a biologically inspired neural network for deciphering anti

biological pathways to drug response prediction. ... informed neural network that exhibits superior performance in drug response prediction.

Predicting Anticancer Drug Response With Deep Learning ...

Then, more drugs whose targets are not on the 46 signaling pathways could be included. Moreover, the graph neural network (GNN) model might be able to model the ...

Hybrid Quantum Neural Network for Drug Response Prediction - MDPI

Finding the dosages that maximize the beneficial effects of the drugs and minimize their adverse side effects is vital. Deep neural networks automate and ...

Biologically-informed neural networks guide mechanistic modeling ...

Biologically-informed neural networks (BINNs), an extension of physics-informed neural networks [1], are introduced and used to discover the underlying ...

Pathway-Guided Deep Neural Network toward Interpretable and ...

In this paper, we presented a pathway-guided deep neural network (DNN) model to predict the drug sensitivity in cancer cells. Biological ...

Cancer Cell on X: "Biologically Informed Neural Networks Predict ...

Biologically Informed Neural Networks Predict Drug Responses https://t.co/p3IDmdxYEZ.