Biphasic decay of the Ca transient results from increased ...

We conclude that, in the presence of adrenergic stimulation, Ca leak can produce biphasic decay; the slow phase results from the leak opposing Ca uptake by ...

Biphasic decay of the Ca transient results from increased ... - PubMed

Ca leak from the sarcoplasmic reticulum through the ryanodine receptor (RyR) reduces the amplitude of the Ca transient and slows its rate of ...

Ca leak can also induce Ca waves. At low levels of leak, waves occur. As leak is increased, first biphasic decay and then slowed monophasic ...

Biphasic decay of the Ca transient results from increased ...

In heart failure, a reduction in Ca transient amplitude and contractile dysfunction can by caused by Ca leak through the sarcoplasmic reticulum (SR) Ca cha.

Biphasic decay of the Ca transient results from increased ...

In heart failure reduction in Ca transient amplitude and contractile dysfunction can by caused by Ca leak through the sarcoplasmic reticulum (SR) Ca channel ...

Caffeine produces a biphasic decay of the Ca transient A, upper panel

... The steep dependence between leak and load of SR is even manifested during a normal CaT decay, during which the SR calcium content increases and Ca 2+ ...

The Control of Diastolic Calcium in the Heart | Circulation Research

The rate of this decay would be expected to affect end-diastolic [Ca2+]i since, all other things being equal, a faster decay will mean that [Ca2 ...

Calcium Buffering in the Heart in Health and Disease | Circulation

Subsequent work found a decrease of both the amplitude and rate constant of decay of the Ca2+ transient because, the higher the buffer power, ...

Journal of Physiology on X: "Biphasic decay of the Ca transient ...

Biphasic decay of the Ca transient results from increased sarcoplasmic reticulum Ca leak #OpenAccess https://t.co/UDr0h6nKZE.

Biphasic increase in intracellular calcium induced by platelet ...

This secondary Ca 2÷ increase is blocked by 10-50/tM lanthanum. At low PAF concentration, the initial Ca z+ transient is not followed by a second phase, showing ...

Cellular shortening and calcium dynamics are improved by noisy ...

Ca2+ transient amplitude and raise rate variables were registered to measure Ca2+ transients. Our results for cell shortening, Ca2+ transient ...

Removal of Ca2+ following depolarization-evoked cytoplasmic ...

The removal after small transients (<82 nM peak [Ca2+]i) had monophasic time course (time constant of 6.43±0.48 s). In the cases of higher Ca2+ transients ...

ca transient amplitude: Topics by Science.gov

On the other hand, both 0.3 and 1 microM SEA0400 significantly increased the decay time constant of [Ca2+]i transients, obtained by fitting its descending limb ...

Systolic [Ca2+]i regulates diastolic levels in rat ventricular myocytes

As the frequency of stimulation increased, the Ca transient amplitude decreased slightly and diastolic [Ca2+]i increased. The decrease in Ca ...

Calcium Transients in Infant Human Atrial Myocytes - Nature

Therefore, it is likely that a combination of increased SR load and increased Ca2+ trigger as a result of changes in the early repolarization ...

Effects of tetracaine on transient decay and NCX function. A, Systolic...

Traces show average systolic Ca 2 transient traces (a); normalized data (b); tail currents associated with Ca 2 transients (c); and rate constants of decay of ...

An Excel based program for the analysis of intracellular calcium ...

Biphasic decay of the Ca transient results from increased sarcoplasmic reticulum Ca leak ... decay and both biphasic decay and slowed monophasic decay are seen.

Physiology of intracellular calcium buffering

... Ca transient (FIGURE 12A). In contrast (FIGURE 12B), the slow buffer NP-EGTA results in a biphasic decay (cf. FIGURE 8 and FIGURE 9).

IP3 mediated global Ca2+ signals arise through two temporally and ...

We find the rising phase of global Ca 2+ signals is punctuated by a flurry of puffs, which terminate before the peak by a mechanism involving partial ER Ca 2+ ...

Calcium-Mediated Oscillation in Membrane Potentials and Atrial ...

Biphasic decay of the Ca transient results from increased sarcoplasmic reticulum Ca leak. J. Physiol. 594, 611–623. doi: 10.1113/JP271473. PubMed Abstract ...