Blockade of endothelial adenosine receptor 2 A suppresses ...

Blockade of endothelial adenosine receptor 2 A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition.

This study discloses a new link between endothelial ADORA2A and EndMT and indicates that inhibiting endothelial ADORA2A could be an effective novel strategy.

(PDF) Blockade of endothelial adenosine receptor 2 A suppresses ...

Purpose: Endothelial-mesenchymal transition (EndMT) leading to endothelial dysfunction, inflammation and disruption of endothelial barrier, ...

Blockade of endothelial adenosine receptor 2A suppresses ...

Blockade of endothelial adenosine receptor 2A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition.

Blockade of A2A receptors potently suppresses the metastasis of ...

CD73 inhibits antitumor immunity through the activation of adenosine receptors expressed on multiple immune subsets.

Inactivation of adenosine receptor 2A suppresses endothelial-to ...

Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. 2 Department of Ophthalmology, University ...

Blockade of endothelial ... - Institutional Repository of Peking University

Blockade of endothelial adenosine receptor 2 A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition [0].

Blockade of endothelial adenosine receptor 2 A suppresses ... - OUCI

Blockade of endothelial adenosine receptor 2 A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition.

Adenosine Receptor 2A Blockade Increases the Efficacy of Anti–PD ...

Nicole Haynes (Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia), and 4T1.2 cells were obtained from Prof. Robin Anderson (Peter MacCallum Cancer ...

Inactivation of endothelial adenosine A2A receptors protects mice ...

After permeabilizing and blocking, sections were incubated with primary antibodies against mouse A2 receptors (5 μg·ml−1, Millipore Cat# 05 ...

Endothelial adenosine A2a receptor-mediated glycolysis is essential ...

Indeed, blockade of glycolysis by the glycolytic inhibitor 3PO and 2-DG markedly suppresses ADORA2A overexpression-induced endothelial sprouting ...

Adenosine receptor 2A-mediated HIF signaling enhances ... - IOVS

Our past work shows that knockout/blockade of adenosine receptor 2A ... Mechanistically, ADORA2A knockdown in CECs suppressed TGFβ-2-induced EndMT ...

Blockade of A2b Adenosine Receptor Reduces Tumor Growth and ...

Blockade of A2b Adenosine Receptor Reduces Tumor Growth and Immune Suppression Mediated by Myeloid-Derived Suppressor Cells in a Mouse Model of Melanoma1,2.

Myeloid Expression of Adenosine A2A Receptor Suppresses T and ...

These findings suggest that increased cytotoxic activity of NK cells or T cells is important for increasing tumor killing upon A2AR blockade/deletion. Figure 2.

Adenosine A2B Receptor Blockade Slows Growth of Bladder and ...

Abstract. The accumulation of high levels of adenosine in tumors activates A2A and A2B receptors on immune cells and inhibits their ability ...

Adenosine 2A receptor and TIM3 suppress cytolytic killing of tumor ...

Inhibitory receptors, in particular CTLA-4, PD-1, TIGIT, TIM3, and LAG3, impair the anti-tumor immune response. Blocking CTLA-4 and PD-1 is a ...

Endothelial adenosine A2a receptor-mediated glycolysis is essential ...

Blockade of endothelial adenosine receptor 2A suppresses ... 2 expression and angiogenic activity of endothelial cells. Expand. 206 ...

Targeting adenosine for cancer immunotherapy

Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors. ... Adenosine receptor 2A blockade increases the efficacy of anti-PD-1 ...

[PDF] Adenosine A2B Receptor Blockade Slows Growth of Bladder ...

The accumulation of high levels of adenosine in tumors activates A2A and A2B receptors on immune cells and inhibits their ability to suppress tumor growth.

Focusing on Adenosine Receptors as a Potential Targeted Therapy ...

Activation of A2AARs inhibits neutrophil adhesion to endothelial cells, formation of reactive oxygen species, and adherence of N-formyl methionyl-leucyl- ...