Blood Pressure Polygenic Risk Score Associated with ...

Polygenic risk scores associate with blood pressure traits across the ...

Genetic risk factors are associated with BP traits across the lifespan, beginning in the first years of life. Given the importance of ...

Evaluating the use of blood pressure polygenic risk scores across ...

We assess performance and limitations of polygenic risk scores (PRSs) for multiple blood pressure (BP) phenotypes in diverse population groups.

Polygenic Risk Scores Predict Hypertension Onset and ...

Systolic and diastolic blood pressure polygenic risk scores improved clinical risk prediction of hypertension, increasing the C statistics by ...

Polygenic risk scores associate with blood pressure traits across the ...

Polygenic risk scores associate with blood pressure traits across the lifespan. Karsten Øvretveit, Karsten Øvretveit KG Jebsen Centre for Genetic Epidemiology.

Blood Pressure Polygenic Risk Score Associated with ...

A polygenic risk score aggregates the risk associated with many common DNA sequence variants into a single factor. The current study examined a ...

Blood Pressure Polygenic Scores Are Associated with Apparent ...

Associations between SBP and DBP polygenic risk scores (PRS) and measured BP were validated in the UK Biobank, excluding overlap with Giri et al., (nmax ...

Utility of a Systolic Blood Pressure Polygenic Risk Score With ...

Importance The clinical utility of polygenic risk scores (PRS) for blood pressure (BP) response to antihypertensive treatment (AHT) has not been ...

BP Polygenic Risk Scores May Complement Measured BP for CVD ...

BP genetic risk identified one in 10 normotensive individuals who had comparable CVD risk as those with untreated hypertension even after ...

Polygenic Risk Scores Predict Hypertension Onset ... - AHA Journals

mation in isolation to predict hypertension onset by constructing genetic risk scores (GRSs) from genetic variants associated with blood pressure (BP).7–13 ...

Blood pressure polygenic risk scores tackle hard endpoints - Nature

Polygenic risk scores (PRS) are currently the most informative way of quantifying genetic burden for BP traits and hypertension.

Study uncovers the role of polygenic risk scores in hypertension ...

UAB researchers explore how polygenic risk scores can refine treatment decisions for patients with high blood pressure.

Utility of a Systolic Blood Pressure Polygenic Risk Score With ...

Elevated blood pressure (BP) is determined by a complex interplay between life-course exposures and genetics, and studies of HTN estimate ...

polygenic risk scores predict hypertension onset and cardiovascular ...

Compared to having an average PRS, elevated PRS was associated with up to 2.3-fold risk of hypertension and an 11-year earlier disease onset (Figure). In ...

Polygenic risk scores associate with blood pressure traits across the ...

Blood pressure (BP) traits have a strong genetic component that can be quantified with polygenic risk scores (PRSs). To date, the performance of BP PRSs has ...

Systolic BP Polygenic Risk Score With Chlorthalidone Response

Systolic blood pressure (SBP) polygenic risk score (PRS) was associated with SBP response to chlorthalidone, but not lisinopril, using two ...

Life-Course Associations between Blood Pressure-Related ... - MDPI

The multi-ancestry genome-wide polygenic risk scores (PRSs) for systolic BP (SBP), diastolic BP (DBP), and hypertension were tested for an association with ...

Polygenic Risk Scores for Blood Pressure to Assess the Risk of ...

The most significant PRS (quantitative)-hypertension association included up to 67 single-nucleotide variants (SNPs) associated with SBP (P = ...

Associations of polygenic risk scores for preeclampsia and blood ...

BP-PRS is strongly associated with hypertensive disorders of pregnancy. Our current observations suggest that the BP-PRS could capture the genetic architecture ...

A multi-ethnic polygenic risk score is associated with hypertension ...

Conclusions: The multi-ethnic HTN-PRS is associated with both prevalent and incident hypertension at 4-6 years of follow up across adulthood and ...

Polygenic Risk Scores Predict Blood Pressure Treatment Response ...

Individuals at enhanced polygenic risk of high systolic blood pressure had increased treatment resistance risk and less pronounced response ...