Building a molecular reference map of the human embryo

Building a molecular reference map of the human embryo - Nature

Two independent studies provide comprehensive human embryo reference maps by integrating multiple human embryo single-cell RNA sequencing ...

A comprehensive human embryo reference tool using single-cell ...

... create a transcriptional reference map of human embryonic development from zygote to gastrula ... human development share the same molecular ...

Tridimensional Visualization and Analysis of Early Human ...

We have generated 3D images of human embryos at an unprecedented cellular resolution. This work offers a unique opportunity to start building a ...

Establishing the molecular blueprint of early embryo development

A collaboration of Cambridge researchers has generated the first comprehensive molecular map of mouse early embryo development. · The map charts ...

The Human Cell Atlas - PMC - PubMed Central

An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states ...

A Comprehensive Human Embryogenesis Reference Tool using ...

The usefulness of embryo models hinges on their molecular, cellular and structural fidelities to their in vivo counterparts. To authenticate ...

A roadmap for the Human Developmental Cell Atlas - PMC

... Human Cell Atlas, aims to create a comprehensive reference map of cells during development ... Molecular diversity of midbrain development ...

Molecular 3D-maps unlock new ways of studying human reproduction

Measuring gene activity in three dimensions, researchers have generated molecular maps of the second week of gestation as it has never been seen ...

The single-cell and spatial transcriptional landscape of human ...

Lastly, we identified conserved and distinctive features across species by comparing early embryonic single-cell transcriptomic profiles between ...

3D reconstruction of a gastrulating human embryo - Cell Press

From this spatial transcriptomic dataset, we constructed a 3D model of the CS8 embryo, in which a range of cell subtypes are identified, based on gene ...

Comprehensive cell atlas of the first-trimester developing human brain

To comprehensively map brain cell types and gene expression trajectories during the first trimester, we collected 26 brain specimens spanning 5 to 14 ...

Integrated pseudotime analysis of human pre-implantation embryo ...

To link developmental stage and molecular events, we performed a per-embryo analysis in which cells from the same embryo were analyzed together.

Establishing the Molecular Blueprint of Early Embryo Development

These new maps, which are freely available online for other researchers to use, illustrate the trajectories of cellular development from one ...

Molecular atlases reveal how human cells develop and grow

One atlas maps gene expression within individual cells across 15 fetal tissues. The second atlas maps the chromatin accessibility of individual genes within the ...

Single-nucleus cross-tissue molecular reference maps to decipher ...

Here, we establish a framework for profiling multiple tissues across the human body at single-cell resolution using single nucleus RNA-Seq ( ...

Single-nucleus cross-tissue molecular reference maps toward ...

Here, we applied four single-nucleus RNA sequencing methods to eight diverse, archived, frozen tissue types from 16 donors and 25 samples, ...

A human cell atlas of fetal gene expression - Science

Understanding the trajectory of a developing human requires an understanding of how genes are regulated and expressed. Two papers now present a pooled ...

Embryologie humaine, normale et pathologique - Alain CHEDOTAL

We are trying to build high-resolution cellular maps of human embryonic organs including the nervous system, muscles, vasculature, skeleton and branched organs.

Molecular and Spatial Signatures of Mouse Embryonic Endothelial ...

We established a single-cell transcriptome map of embryonic ECs during key stages of vascular development, identified 19 distinct EC subtypes, ...

Molecular 3D-maps unlock new ways of studying human reproduction

Scientists have identified the biochemical signals that control the emergence of the body pattern in the primate embryo. This will guide work to ...