CAR|T 'robustly effective' in younger patients with deadly form of ...

CAR-T 'robustly effective' in younger patients with deadly form of ...

Younger patients with diffuse midline glioma experienced prolonged clinical improvement after receiving an investigational chimeric antigen ...

Taming the Beast: CRS and ICANS after CAR T-cell therapy for ALL

Treatment with CD19 or CD22-targeted chimeric antigen receptor-engineered T (CD19/CD22 CAR-T) cells achieve complete responses in approximately 60 to 90% of ...

Exploring CAR-T Cell Therapy Side Effects: Mechanisms and ...

Chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of malignancies, especially hematological tumors, ...

CAR-T cell manufacturing: Major process parameters and next ...

Of note, CAR-T cells were detectible at 6 mo after infusion in 93% (13/14) of patients and at 12 mo in 71% (5/7) of patients, indicating robust ...

Locoregional delivery of IL-13Rα2-targeting CAR-T cells in recurrent ...

Stable disease or better was achieved in 50% (29/58) of patients, with two partial responses, one complete response and a second complete ...

Robust Antitumor Activity and Low Cytokine Production by Novel ...

Abstract. Recent studies have described the remarkable clinical outcome of anti-CD19 chimeric antigen receptor (CAR) T cells in treating B-cell.

Toxicity and management in CAR T-cell therapy - ScienceDirect.com

T cells can be genetically modified to target tumors through the expression of a chimeric antigen receptor (CAR). Most notably, CAR T cells have ...

PSCA-CAR T cell therapy in metastatic castration-resistant prostate ...

Despite recent therapeutic advances, metastatic castration-resistant prostate cancer (mCRPC) remains lethal. Chimeric antigen receptor (CAR) ...

Chimeric Antigen Receptor (CAR) T-cell Therapy for Cancers - CMS

According to the NCI (2017d), "in nearly all patients the problem is short lived and reversible." Finally, a significant toxicity of some CAR T-cell therapy is ...

Management of Immune-Related Adverse Events in Patients ...

Immunotherapy has revolutionized the treatment of many different types of cancers. Chimeric antigen receptor T-cell (CAR T) therapy is an expanding ...

Study reveals possible key to long-term survival among CAR T ...

Chimeric antigen receptor (CAR) T therapy has proven to be highly effective in treating some blood cancers, with more than 90% of patients ...

Cytokines in CAR T Cell–Associated Neurotoxicity - Frontiers

Chimeric antigen receptor (CAR) T cells provide new therapeutic options for patients with relapsed/refractory hematologic malignancies.

CAR T Cells: Engineering Immune Cells to Treat Cancer - NCI

Since 2017, six CAR T-cell therapies have been approved by the Food and Drug Administration (FDA). All are approved for the treatment of blood ...

Cancer fighting cells | Summer 2022 Synthesis - UC Davis Health

CAR T-cell therapy is highly effective but comes with the risk of serious side effects. As the CAR T cells multiply in the body, they can release chemicals ...

CAR T-Cell Therapy Approved for Children, Young Adults with ...

Tisagenlecleucel (Kymriah™), a form of CAR T-cell therapy, has been approved by FDA for some children and young adults with advanced acute ...

Novel CAR T therapy is a ray of hope in the treatment of seriously ill ...

Interestingly, CAR T cells are effective against both solid tumors and hematological cancers such as AML. Gradually, CAR T cell therapy found ...

Considerations for the Development of Chimeric Antigen Receptor T ...

event that additional analysis is necessary. If an autologous CAR T cell clinical study will enroll patients who have received CAR T cells previously and ...

CAR T cells and time-limited ibrutinib as treatment for relapsed ...

CD19-directed chimeric antigen receptor T cells (CAR-T) achieve high response rates in patients with relapsed/refractory mantle cell lymphoma ( ...

CAR T-cell Therapy and Its Side Effects | American Cancer Society

Chimeric antigen receptor (CAR) T-cell therapy is a way to get immune cells called T cells (a type of white blood cell) to fight cancer by ...

Review Frontiers in CAR-T cell therapy for autoimmune diseases

Chimeric antigen receptor (CAR)-engineered T (CAR-T) cell therapy has demonstrated significant success in treating cancers. The potential of CAR ...