CD4 and CD8 T cells require different membrane gangliosides for ...

While investigating T-cell activation in ganglioside-deficient mice, we observed that CD4(+) and CD8(+) T cells required different ganglioside subsets for ...

While investigating T-cell activation in ganglioside-deficient mice, we observed that CD4 + and CD8 + T cells required different ganglioside subsets for ...

Distinct selectivity of gangliosides required for CD4⁺ T and CD8⁺ T ...

Molecules called gangliosides are known to be major components of lipid rafts, but their role in T-cell activation remains to be elucidated. This review ...

Distinct selectivity of gangliosides required for CD4 + T and CD8 + T ...

CD8T cells require o-series gangliosides for activation. •. GM3 synthase null mice are resistant to develop experimental asthma. •. CD4T and CD8T ...

[PDF] Distinct selectivity of gangliosides required for CD4⁺ T and ...

Distinct selectivity of gangliosides required for CD4⁺ T and CD8⁺ T cell activation. ... CD4 and CD8 T cells require different membrane gangliosides for ...

Distinct selectivity of gangliosides required for CD4+ T and CD8+ T ...

This review summarizes recent findings that different types of T cells require distinct ganglioside types for the activation. Control of ganglioside ...

Distinct Selectivity of Gangliosides Required for CD4

... T,. Iwasaki K, Fujiwara M, Takayanagi M, Ohno I, Inokuchi J (2012). CD4 and CD8 T cells require different membrane gangliosides for activation. Proc. Natl ...

Gangliosides in T Cell Immunity - SpringerLink

To ensure that CD4 and CD8 are moved to a proper place on the membrane, it might be vital for CD4/CD8 to interact with rafts carrying a specific ganglioside ...

The regulatory roles of glycosphingolipid‐enriched lipid rafts in ...

In contrast, a-series and o-series gangliosides form distinct rafts on CD4+ and CD8+ T cell subsets, respectively, contributing to the ...

Transcriptional Regulation of T-Cell Lipid Metabolism - Frontiers

... T, et al. CD4 and CD8 T cells require different membrane gangliosides for activation. Proc Natl Acad Sci U S A (2012) 109(6):E336–42. doi:10.1073/pnas ...

Citations to this article in year 2012 (4) - JCI

CD4 and CD8 T cells require different membrane gangliosides for activation. M Nagafuku, K Okuyama, Y Onimaru, A Suzuki, Y Odagiri, T Yamashita, K Iwasaki, M ...

CD38 in SLE CD4 T cells promotes Ca 2+ flux and suppresses ...

CD4 and CD8 T cells require different membrane gangliosides for activation. Proc. Natl Acad. Sci. USA 109, E336–E342 (2012). Article CAS ...

Activation of human naïve Th cells increases surface expression of ...

In T cells, the lipid rafts can isolate on membrane ... CD4 and CD8T cells require different membrane gangliosides for activation.

The Role of Glycosphingolipids in Immune Cell Functions - Frontiers

... T, et al. CD4 and CD8 T cells require different membrane gangliosides for activation. Proc Natl Acad Sci USA. (2012) 109:E336–42. doi: 10.1073/pnas ...

Cd8-t-cell-activation-markers | Sigma-Aldrich

CD4 and CD8 T cells require different membrane gangliosides for activation. Masakazu Nagafuku et al. Proceedings of the National Academy of Sciences of the ...

Ganglioside Inhibition of CD8 + T Cell Cytotoxicity - AAI Journals

Thus, tumor-shed gangliosides suppress lytic activity of CD8+ T cells by a novel mechanism, that is, inhibition of trafficking of lytic granules in response to ...

Gangliosides in T cell development and function of mice

The same questions apply to GSLs involved in T cell development and activation. Primary CD4⁺ T cells and CD8⁺ T cells preferentially express ...

The interplay between membrane topology and mechanical forces ...

The T cell surface is rich with co-receptors that play fundamental roles in T cell activation. CD4 consists of 4 Ig-like domains tilted from the ...

Preparation of CD4+ T Cells for Analysis of GD3 and GD2 ...

PNAS Plus: CD4 and CD8 T cells require different membrane gangliosides for activation. Procs Natl Acad Sci USA. 109 (6), E336-E342 (2012). Schnaar, R. L. ...

T Cells: Types and Function - Cleveland Clinic

The T cell binds to the MHC. There are two types of MHC. One fits each type of T cell. The CD8 receptor on a cytotoxic T cell can only bind to MHC-1 ...