CD56 bright NK cells are more metabolically active ...

Metabolic Reprogramming Supports IFN-γ Production by ... - PubMed

Overall, we have defined CD56(bright) NK cells to be more metabolically active than CD56(dim) cells, which supports their production of large ...

Metabolic Reprogramming Supports IFN-γ Production by CD56 ...

Overall, we have defined CD56bright NK cells to be more metabolically active than CD56dim cells, which supports their production of large amounts of IFN-γ ...

Advances in metabolic reprogramming of NK cells in the tumor ...

Human blood NK cells are divided into two main subpopulations: the CD56bright and CD56dim NK cells. CD56dim cells have higher cytotoxicity ...

CD56 bright NK cells are more metabolically active ... - ResearchGate

In peripheral blood, the CD56 bright NK cell subset exhibited superior metabolic activity in comparison to CD56 dim cells [153] . In response to cytokine ...

What Defines NK Cell Functional Fate: Phenotype or Metabolism?

In their most classic definition, human NK cells are broadly dichotomized into CD56brightCD16− regulatory NK cells with greater cytokine-producing ...

The role of CD56bright NK cells in neurodegenerative disorders

CD56bright NK cells are potent cytokine secretors and are considered more immunoregulatory and less terminally differentiated than their mostly ...

Dysregulation of Metabolic Pathways in Circulating Natural Killer ...

Human peripheral blood NK cells can be functionally divided into two subsets based on the level of surface expression of CD56 [CD56dim and CD56 ...

CD56 bright NK cells exhibit potent antitumor responses following IL ...

While CD56dim NK cells are considered more differentiated than the CD56bright subset, they still exist within a range of maturity states. NK ...

The Tumor Microenvironment—A Metabolic Obstacle to NK Cells ...

CD56bright NK cells have a higher capacity for cytokine production; however, they have relatively low cytotoxicity in comparison to CD56dim cells [5]. NK cells ...

Metabolism of NK cells during viral infections - Frontiers

In functional phenotype, NK cells with cytotoxic activity (CD56dim) maintain higher rates of glycolysis and OXPHOS than cytokine-producing NK cells (CD56bright) ...

CD56 does not contribute to the antitumor, tissue homing, and ...

CD56bright and CD56dim NK cells also differ in their use of metabolic pathways to sustain energy demands during cytokine activation. CD56bright ...

Metabolic changes of Interleukin-12/15/18-stimulated human NK cells

We cultured control and activated NK cells with low doses of IL-15 (1 ng/mL) for seven days, as others have previously done, to support their ...

Modulating NK cell metabolism for cancer immunotherapy

In the case of human NK cells, it has been demonstrated that, even if both CD56bright and CD56dim subsets have metabolic changes in response to cytokine ...

(PDF) Metabolic Reprogramming Supports IFN-γ Production by ...

Overall, we have defined CD56(bright) NK cells to be more metabolically active than CD56(dim) cells, which supports their production of large amounts of IFN-γ ...

Optimising NK cell metabolism to increase the efficacy of cancer ...

CD56bright NK cells are the major producers of cytokines including IFN-γ (interferon-γ) and TNF-α (tumour necrosis factor-α), while CD56dim NK ...

CD56 bright NK Cells Are Enriched at Inflammatory Sites and Can ...

In peripheral blood, CD56dim NK cells dominate, whereas in lymph nodes, CD56bright NK cells are more common. In this study we show that CD56bright NK cells ...

Intrinsic and extrinsic factors determining natural killer cell fate

CD56bright CD16- NK cells are dominant in tissues with low cytotoxicity, but can produce more cytokines [1]. NK cells are functionally similar to CD8+ cytotoxic ...

A NKp80-Based Identification Strategy Reveals that CD56 neg NK ...

Natural killer (NK) cells are usually identified by the absence of other lineage markers, due to the lack of cell-surface-specific receptors ...

CD25bright NK cells display superior function and metabolic activity ...

Compared with CD25dim NK cells, CD25bright NK cells isolated from IL-15 primed NK cells display increased proliferative and metabolic activity ...

Exercise-Dependent Regulation of NK Cells in Cancer Protection

By contrast, evaluation of human peripheral NK cells have shown that. CD56bright NK cells are more metabolically active than CD56dim NK cells, and while the.