Calcium signaling in neurodegeneration

A sustained increase in intracellular calcium can, per se, lead to neurodegeneration and cell death. However, calcium homeostasis deregulation ...

Review Calcium signaling and molecular mechanisms underlying ...

It is clearly demonstrated that calcium signaling dysregulation is a common feature of neurodegenerative diseases. Abnormal Ca2+ signaling leads to ...

Calcium signaling and molecular mechanisms underlying ...

It is clearly demonstrated that calcium signaling dysregulation is a common feature of neurodegenerative diseases. Abnormal Ca2+ signaling leads to ...

Review Calcium signaling and molecular mechanisms underlying ...

Highlights · Calcium (Ca2+) signaling is dysregulated in aging neurons and in neurons affected by neurodegenerative disorders. · Elevated endoplasmic reticulum ( ...

The Interplay between Ca2+ Signaling Pathways and ... - MDPI

Calcium (Ca2+) homeostasis is essential for cell maintenance since this ion participates in many physiological processes. For example, the spatial and ...

Cholesterol, Calcium Signaling, and Neurodegeneration

Disruption in cholesterol homeostasis has been linked to Alzheimer's, Parkinson's, and Huntington's Disease while alterations in calcium ...

Targeting calcium signaling in Alzheimer's disease: challenges

The critical role of calcium dyshomeostasis in the pathogenesis of Alzheimer's disease (AD): AD is a progressive neurodegenerative disease characterized by ...

Calcium signaling and neurodegenerative diseases - Cell Press

Recent evidence indicates that neuronal calcium (Ca2+) signaling is abnormal in many of these disorders. Similar, but less severe, changes in ...

Mitochondria and Calcium Regulation as Basis of ... - Frontiers

Recent findings have shown that mitochondrial fitness is tightly regulated by Ca2+ signals, which are altered long before the onset of measurable histopathology ...

Calcium dyshomeostasis and intracellular signalling in alzheimer's ...

Dysregulation of intracellular calcium signalling has been implicated in the pathogenesis of Alzheimer's disease. Increased intracellular ...

Role of Calcium Modulation in the Pathophysiology and Treatment ...

Alterations in calcium signaling can be caused by Aβ-soluble oligomers, which are produced by the abnormal cleavage of the APP by the enzymes β-secretase 1 and ...

Mitochondrial calcium signalling and neurodegenerative diseases

Mitochondria actively contribute to buffering cellular calcium, but if matrix calcium increases beyond physiological demands, it can promote opening of the ...

Calcium Signaling Deficits in Glia and Autophagic Pathways ...

The original Ca2+ hypothesis of aging and neurodegeneration is based on the premise that altered Ca2+ homeostasis disrupts a host of critical signaling cascades ...

Calcium and cell death signaling in neurodegeneration and aging

Calcium homeostasis was also shown to be an important mechanism involved in neurodegenerative and aging processes. calcium; apoptosis; Bax; mitochondria; ...

Astrocytic Calcium and cAMP in Neurodegenerative Diseases

It is worth noting that the ventral midbrain-derived astrocytes are highly susceptible to D2 receptor-induced Ca2+ signaling. They seem to be relatively ...

Dysfunction of neuronal calcium signaling in aging and disease

Calcium plays a critical role in the regulation of neuronal excitability. This can be achieved directly, via the modulation of the activity of ...

Calcium signaling and neurodegenerative diseases | Request PDF

... Under physiological conditions, calcium signaling plays a critical role in communication between astrocytes and neurons, while dysregulated cellular calcium ...

Cholesterol, Calcium Signaling, and Neurodegeneration

Disruption in cholesterol homeostasis has been linked to Alzheimer's, Parkinson's, and Huntington's Disease while alterations in calcium signaling is ...

Calcium Signaling in Neurodegeneration : A Review

Normal aging causes alterations in neuronal Ca2+ signaling that are similar but less drastic. Here, we address the dysregulation of calcium in a ...

Deranged Calcium Signaling and Neurodegeneration in ...

We extended these findings to the analysis of SCA3-YAC-84Q mouse model. Obtained results suggested that deranged neuronal Ca2+ signaling plays a ...