Can adenosine A2A receptor antagonists modify motor behavior ...

This paper reviews the preclinical evidence base for the ability of adenosine A 2A receptor blockade to influence motor function and modulate dyskinesia ...

There is consensus that adenosine A2A receptor antagonists - administered either as a monotherapy or in combination with l-DOPA or dopamine agonists - improve ...

How do adenosine A2A receptors regulate motor function?

Adenosine A2A antagonists act to normalize the activity of the indirect pathway in PD. Abstract. Adenosine A2A receptor antagonism is a new therapeutic strategy ...

Motor stimulant effects of the adenosine A2A receptor antagonist ...

Motor stimulant effects of the adenosine A2A receptor antagonist SCH 58261 do not develop tolerance after repeated treatments in 6-hydroxydopamine-lesioned rats.

Can adenosine A>2A> receptor antagonists modify motor behavior ...

Current treatment of the motor symptoms of Parkinson's disease (PD) focuses on dopamine replacement therapies. While these treatments are initially highly ...

Can adenosine A2A receptor antagonists modify motor behavior ...

There is consensus that adenosine A2A receptor antagonists – administered either as a monotherapy or in combination with l-DOPA or dopamine agonists – improve ...

A Meta-Analysis of Adenosine A2A Receptor Antagonists ... - Frontiers

The improvement in LID behavior without an impact of motor function is highly significant as it differentiates A2A receptor antagonists from the known effects ...

The Pharmacological Potential of Adenosine A2A Receptor ... - MDPI

... adenosine A2A receptor antagonists from the perspective of the treatment of both motor and non-motor symptoms of PD and their potential for disease modification

Can adenosine A2A receptor antagonists modify motor behavior ...

Can adenosine A2A receptor antagonists modify motor behavior and dyskinesia in experimental models of Parkinson's disease? https://doi.org/10.1016/j ...

Rescue of Locomotor Impairment in Dopamine D2 Receptor ...

In this article, D2R−/− mice were used to explore the possibility that an A2AR antagonist might reestablish their motor impairment.

Involvement of Adenosine A1 and A2A Receptors in the Motor ...

More than a synergistic effect, our results showed evidence for and additive motor activating effect of A1 and A2A receptor antagonists. Thus, a ...

Adenosine A2A antagonists in Parkinson's disease: what's next?

Non-dopaminergic medications that improve PD symptoms and motor fluctuations are in demand. Adenosine A2A receptors are abundantly expressed within the basal ...

Can adenosine A2A receptor antagonists modify motor behavior ...

DOI: 10.1016/J.PARKRELDIS.2020.09.026) This article is published in Parkinsonism & Related Disorders. The article was published on 01 Nov 2020. and is ...

November 2020 - Parkinsonism & Related Disorders

Can adenosine A2A receptor antagonists modify motor behavior and dyskinesia in experimental models of Parkinson's disease · Can adenosine A2A receptor ...

Increased adenosine A2A receptors in the brain of Parkinson's ...

These findings suggest that increased synthesis of adenosine A 2A receptors in striatopallidal pathway neurons is associated with the development of ...

The Pharmacological Potential of Adenosine A2A Receptor ...

They suggest that, while an adenosine, A2A antagonist will antagonize the braking effect of adenosine on motor control via suppression of ...

How do adenosine A2A receptor antagonists impact the non-motor ...

Find out what the research says about 'How do adenosine A2A receptor antagonists impact the non-motor symptoms of Parkinson's disease?'

Two new adenosine receptor antagonists for the treatment of ...

Conversely, A2A receptor antagonists cause increased movement and behavioral activation. ... Adenosine A2A receptors modify motor · function in MPTP-treated ...

Role of adenosine A2A receptors in motor control - ResearchGate

In this review, we provide an overview of the effects that adenosine A2A receptor antagonists elicit in rodent and primate experimental models of PD, with ...

Istradefylline – a first generation adenosine A 2A antagonist for the ...

Adenosine A2A receptor antagonists represent a new way forward in the symptomatic treatment of PD. Areas covered In this narrative review, we summarize the ...