Cancer Drug Resistance

Cancer Drug Resistance - OAE Publishing Inc.

Cancer Drug Resistance is a peer-reviewed journal led by Editor-in-Chief Godefridus J. (Frits) Peters, covering drug resistance research on breast cancer, ...

A view on drug resistance in cancer | Nature

We propose four general solutions to drug resistance that are based on earlier detection of tumours permitting cancer interception; adaptive monitoring during ...

Unveiling the mechanisms and challenges of cancer drug resistance

Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer treatment strategies are evolving due to innate and ...

The Different Mechanisms of Cancer Drug Resistance: A Brief Review

The drug resistance can be occurred by different mechanisms, including multi-drug resistance, cell death inhibiting (apoptosis suppression), altering in the ...

Why Do Cancer Treatments Stop Working? - NCI

Resistance can occur when cancer cells—even a small group of cells within a tumor—contain molecular changes that make them insensitive to a ...

Mechanisms of Multidrug Resistance in Cancer Chemotherapy - PMC

The mechanisms of MDR include elevated metabolism of xenobiotics, enhanced efflux of drugs, growth factors, increased DNA repair capacity, and genetic factors.

Hallmarks of cancer resistance: iScience - Cell Press

This resistance is characterized by the remarkable ability of cancer cells to evade the cytotoxic effects of treatments, thereby compromising ...

Multidrug Resistance in Cancer: Understanding Molecular ...

This review describes the known MDR mechanisms in cancer cells and discusses ongoing laboratory approaches and novel therapeutic strategies

Preventing Resistance to Cancer Targeted Therapies - NCI

The research focused on metastatic melanoma. Several targeted drugs are standard treatments for this aggressive form of skin cancer. When ...

Cancer drug resistance causes and categories identified - EMBL-EBI

Researchers uncover that DNA changes that cause cancer drug resistance can be grouped into four categories, and identify possible new therapeutic targets.

Base editing screens define the genetic landscape of cancer drug ...

Drug resistance is frequently caused by DNA single nucleotide variants (SNVs) in the cancer genome, leading to point mutations in the drug ...

Overcoming drug resistance in cancer - Cell Press

A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAF V600E colorectal tumors.

Multi drug resistance in Colorectal Cancer- approaches to overcome ...

We discussed the unique instance of multidrug resistance in colorectal cancer in malignancies generally and 5-fluorouracil, curcumin, and lipids as viable ...

Drug Resistance in Cancer: An Overview - MDPI

This paper outlines the current knowledge of mechanisms that promote or enable drug resistance, such as drug inactivation, drug target alteration, drug efflux, ...

Drug Resistance and the Solid Tumor Microenvironment | JNCI

In this review, we describe how the tumor microenvironment may be involved in the resistance of solid tumors to chemotherapy and discuss potential strategies.

Mechanisms of Cancer Drug Resistance - Annual Reviews

Abstract The design of cancer chemotherapy has become increasingly sophisticated, yet there is no cancer treatment that is 100% effective ...

Drug Resistance in Cancer: Mechanisms and Models - ATCC

Cell-based models are critical tools for understanding the mechanisms of drug resistance and developing novel therapeutics. The most common method for ...

Anticancer drug resistance: An update and perspective - ScienceDirect

Multiple studies revealed that cancer drug resistance is based upon a plethora of distinct mechanisms. Drug resistance mutations can occur in the same protein ...

Genetic heterogeneity and cancer drug resistance - The Lancet

Although cancers are traditionally thought to be clonal, there is now evidence of intra-tumour genetic heterogeneity in most cancers.

Drug Resistance - COSMIC

This can be caused by the development of resistance mutations, such as those in the drug target preventing drug binding. Acquired resistance develops gradually ...