Carboplatin dosing in the era of IDMS|creatinine

Carboplatin dosing in the era of IDMS-creatinine - PubMed

We hypothesized that GFR calculated using IDMS-creatinine in the CG formula (CG-GFR) exposes patients to inaccurate carboplatin dosing.

Carboplatin dosing in the era of IDMS-creatinine; the Cockroft-Gault ...

We hypothesized that GFR calculated using IDMS-creatinine in the CG formula (CG-GFR) exposes patients to inaccurate carboplatin dosing.

Carboplatin dosing in the era of IDMS-creatinine; the Cockroft-Gault ...

We hypothesized that GFR calculated using IDMS-creatinine in the CG formula (CG-GFR) exposes patients to inaccurate carboplatin dosing.

Carboplatin dosing in the era of IDMS-creatinine

Glomerular filtration rate (GFR) measured by Chromium-51-EDTA excretion (51Cr-GFR) is con- sidered the gold standard of renal function ...

Carboplatin dosing in the era of IDMS-creatinine; the Cockroft-Gault ...

Conclusions: The convention of considering AUC5 carboplatin based on 51Cr-GFR, and AUC6 carboplatin based on CG-GFR as equivalent is invalid and should be ...

Carboplatin Dosing on the Basis of Renal Function: 30+ Years after ...

When the resulting AUC is considered, the formula derived was dose (mg)=target AUC ([mg/ml]×min)×(GFR+25) (ml/min). For the pharmacodynamic aspect of the study, ...

Carboplatin Dosing on the Basis of Renal Function - Kidney360

It was found that the total body clearance of carboplatin was equal to the GFR (ml/min) (renal clearance) plus 25 ml/min (nonrenal clearance). When the ...

Carboplatin dosing in the era of IDMS-creatinine - ResearchGate

Carboplatin dosing in the era of IDMS-creatinine; the Cockroft-Gault formula no longer provides a sufficiently accurate estimate of glomerular filtration rate ...

Adjustment of creatinine clearance for carboplatin dosing in ...

The Cockcroft–Gault formula is commonly used as a substitute for glomerular filtration rate (GFR) in Calvert's formula for carboplatin dosing, ...

Tolerability of Carboplatin When Using Rounded Serum Creatinine ...

This formula—dose (mg) = AUC (mg/mL-1 min) × [GFR (mL/min) + 25 (mL/min)]—has proved to be a reliable tool to calculate the optimal dose of carboplatin in ...

Glomerular filtration rate estimation for carboplatin dosing in patients ...

20. McLean, L. ∙ Whittle, J.R. ∙ Graham, J. ... Carboplatin dosing in the era of IDMS-creatinine; the Cockroft-Gault formula no longer ...

Carboplatin dose calculation in lung cancer patients with low serum ...

AUC: area under the concentration time curve; CrCl: creatinine clearance; SCr: serum creatinine; GFR: glomerular filtration rate; CG: Cockcroft–Gault; BMI ...

Flat Dosing of Carboplatin Is Justified in Adult Patients with Normal ...

The most simple and widely used formula to calculate the carboplatin dose was proposed by Calvert et al. (12), relating the ultrafilterable AUC to the GFR by ...

Optimizing carboplatin dosing by an improved prediction of ...

Carboplatin is generally dosed based on a modified Calvert formula, in which the Cockcroft–Gault-based creatinine clearance (CRCL) is used ...

Carboplatin dosing in the treatment of ovarian cancer: An NRG ...

The formula used to estimate CrCl affects carboplatin dosing. · Estimated creatinine clearance (CrCl) <60 mL/min (by Jelliffe) did not accurately predict adverse ...

Improving Carboplatin Dosing Based on Estimated GFR

Index tests included 7 existing creatinine-based. eGFR equations and 1 new equation derived in the devel- opment data set, with and without ...

Carboplatin AUC Dosing (Calvert) - Medscape

... carboplatin plasma concentration versus time curve) while taking into account renal function. Please note that dose is provided in mg not mg/m2. This dosing ...

Impact of a new assay for measuring serum creatinine levels on ...

Carboplatin dosing in the era of IDMS-creatinine; the Cockroft-Gault formula no longer provides a sufficiently accurate estimate of glomerular filtration rate ...

The impact of clinical equations on carboplatin dosing: A systematic ...

Equations like Modification of Diet in Renal Disease or CKD-EPI (based on serum creatinine (SrCr) or cystatin C), take into account parameters ...

Multi-Institutional Validation Study of Carboplatin Dosing Formula ...

Creatinine clearance (Ccr) is widely used as a practical substitute for glomerular filtration rate (GFR) in the Calvert formula: carboplatin dose (mg) ...