Characterization of the Tumor Microenvironment in Osteosarcoma ...

Our analysis revealed that TMEscore high correlates with longer survival in OS patients, elevated immune cell infiltration, increased immune ...

Characterizing the tumor microenvironment at the single-cell level ...

The immune microenvironment extensively participates in tumorigenesis as well as progression in osteosarcoma (OS).

Characterization of the Tumor Microenvironment in Jaw ... - MDPI

Background—The purpose of this study was to investigate the bone resorption, as well as the vascular and immune microenvironment, of jaw osteosarcomas (JO) ...

Unlocking the tumor-immune microenvironment in osteosarcoma

An analysis of a single-cell atlas of osteosarcoma and myeloid cells revealed that mature immunoregulatory dendritic cells (mregDCs), which are abundant in ...

Characterization of the Tumor Microenvironment in - ProQuest

The osteosarcoma (OS) microenvironment is composed of tumor cells, immune cells, and stromal tissue and is emerging as a pivotal player in OS development ...

Immunosuppressive tumor microenvironment of osteosarcoma

Additional osteosarcoma samples were profiled using spatial transcriptomics for validation of discovered subtypes and to add spatial context.

A tumor microenvironment-based prognostic index for osteosarcoma

The tumor microenvironment (TME) has a central role in the oncogenesis of osteosarcomas. The composition of the TME is essential for the ...

Decoding the Impact of Tumor Microenvironment in Osteosarcoma ...

Myeloid cells are the most abundant cell type in the TME of OS. A single-cell analysis showed multiple ligand–receptor interactions between OS tumor, myeloid, ...

Characterization of osteosarcoma subtypes mediated by ...

The tumor microenvironment (TME) of osteosarcoma is a very complex and highly dynamic environment composed of osteocytes, stromal cells, ...

Managing the immune microenvironment of osteosarcoma - Nature

However, TAMs usually show an immunosuppressive type-2 phenotype in the tumor microenvironment and are prone to facilitate angiogenesis and ...

Molecular characterization of immunogenic cell death indicates ...

However, the feature of the ICD molecular subtype and the related tumor microenvironment (TME) and immune cell infiltration has not been carefully investigated ...

Research Article Characterization of the Tumor Microenvironment in ...

The osteosarcoma (OS) microenvironment is composed of tumor cells, immune cells, and stromal tissue and is emerging as a.

Comprehensive analysis of prognostic tumor microenvironment ...

Tumor microenvironment (TME) plays an important role in malignant tumors. Our study aimed to investigate the effect of the TME and related ...

Advancing osteosarcoma 3D modeling in vitro for novel tumor ...

OS MCTS innately generated tumor microenvironment (TME) leads to M2-like polarized tumor, resembling OS aggressiveness. •. The heterotypic nature of OS MCTS ...

Characterization of the Tumor Microenvironment in Osteosarcoma ...

The osteosarcoma (OS) microenvironment is composed of tumor cells, immune cells, and stromal tissue and is emerging as a pivotal player in OS development ...

Osteosarcoma is the most prevalent clinical malignant bone tumor in adolescents. The prognosis of metastatic osteosarcoma is still very poor ...

Intratumoral Heterogeneity Assessment of the Extracellular Bone ...

Characterization of macrophages and osteoclasts in the osteosarcoma tumor microenvironment at diagnosis: new perspective for osteosarcoma treatment? Cancers ...

Deciphering the role of the tumor microenvironment in ...

Osteosarcoma is the most common malignant bone tumor in children and adolescents. · The tumor microenvironment releases substances that promote tumor cell ...

(PDF) Characterization of the tumour microenvironment phenotypes ...

Results: Thirteen main cell groups were identified in osteosarcoma tumour and MPE samples. Immune cells dominate the cellular contexts in MPE with more T/NK ...

Characterization of Macrophages and Osteoclasts in the ...

Characterization of Macrophages and Osteoclasts in the Osteosarcoma Tumor Microenvironment at Diagnosis: New Perspective for Osteosarcoma Treatment? 23 Jan 2021 ...