Chemical Biology Approach to Reveal the Importance of Precise ...

We report an oligoguanidine-based peptidomimetic that effectively targets and eradicates intracellular S. aureus persisters in the phagolysosome lumen.

Here, we report an oligoguanidine-based peptidomimetic that effectively targets and eradicates intracellular S. aureus persisters in the ...

Chemical Biology Approach to Reveal the Importance of Precise ...

Intracellular bacterial pathogens pose significant public health challenges due to their ability to evade immune defenses and conventional antibiotics. Drug ...

Chemical Biology Approach to Reveal the Importance of Precise ...

Dive into the research topics of 'Chemical Biology Approach to Reveal the Importance of Precise Subcellular Targeting for Intracellular ...

Chemical Biology Approach to Reveal the Importance of Precise ...

Intracellular bacterial pathogens, such as Staphylococcus aureus, that may hide in intracellular vacuoles represent the most significant manifestation of ...

Chemical Biology Approach to Reveal the Importance of ... - Altmetric

Chemical Biology Approach to Reveal the Importance of Precise Subcellular Targeting for Intracellular Staphylococcus aureus Eradication | Journal of the ...

J. Am. Chem. Soc. on X: "Chemical Biology Approach to Reveal the ...

Chemical Biology Approach to Reveal the Importance of Precise Subcellular Targeting for Intracellular Staphylococcus aureus Eradication ...

[ASAP] Chemical Biology Approach to Reveal the Importance of ...

[ASAP] Chemical Biology Approach to Reveal the Importance of Precise Subcellular Targeting for Intracellular Staphylococcus aureus Eradication · Details · All ...

Chemical Biology Approach to Reveal the Importance of Precise ...

Chemical Biology Approach to Reveal the Importance of Precise Subcellular Targeting for Intracellular Staphylococcus aureus Eradication. Silei Bai, Junfeng ...

A Chemical Biology Approach to the Chaperome in Cancer—HSP90 ...

Here we aim to provide an overview on how chemical biology has played a role in deciphering such complexity in the biology of the chaperome in cancer and in ...

Investigating Nonapoptotic Cell Death Using Chemical Biology ...

Small-molecule phenotypic screening is a powerful means to discover compounds with novel mechanisms of action (Wagner and Schreiber, 2016). Here, libraries of ...

Nature Chemical Biology

Synthesis and characterization of new macrolones — fusions of two antibiotic classes with distinct bacterial targets — reveal the basis for ...

Chemical Biology

Chemical Biology uses chemical approaches to reveal new molecular insights into macromolecules and their complexes with proteins, nucleic acids and/or small ...

Chemical approaches to unraveling the biology of mycobacteria

This review will focus on advances in the chemical biology community over the past ten years as they relate to improving our understanding of the pathogen and ...

A Chemical Proteomics Approach to Reveal Direct Protein-Protein ...

Methods for identifying low-affinity protein-protein interactions are critical for advancing our understanding of important biological processes ...

Phenotype and target-based chemical biology investigations in ...

By analogy to classical genetics, chemical biology can also employ forward and reverse approaches (Fig. 1). Forward or phenotype-based chemical ...

Chemical screening by time-resolved X-ray scattering to discover ...

Biomolecular conformation drives function for many targets of high biological importance, including allosteric assemblies, protein ...

Chemical Biology Gateways to Mapping Location, Association, and ...

Generally, a small molecule used for chemical biology should be as non-invasive as possible. Thus, it should not ideally cause cell death, cell-cycle stall, or ...

A Chemical Biology View of Bioactive Small Molecules and a Binder ...

A Chemical Biology View of Bioactive Small Molecules and a Binder‐Based Approach to Connect Biology to Precision Medicines ... To read the full-text of this ...

AFOSR - Chemistry and Biological Sciences > One AFRL

The primary approach is to discover, develop, and test principles derived ... chemical reactivity and energy flow at a detailed molecular level is of importance.