Chemoresistance in pancreatic ductal adenocarcinoma

Chemoresistance in Pancreatic Cancer - PMC - PubMed Central

Chemoresistance is multifactorial as a result of the interaction among pancreatic cancer cells, cancer stem cells, and the tumor microenvironment.

The challenge of drug resistance in pancreatic ductal adenocarcinoma

Novel gemcitabine conjugated albumin nanoparticles: a potential strategy to enhance drug efficacy in pancreatic cancer treatment.

Chemoresistance in pancreatic ductal adenocarcinoma

In this chapter, we discuss potential causes of PDAC chemoresistance and approaches for combating chemoresistance by targeting different pathways and different ...

Reversing chemotherapy resistance in pancreatic cancer

“We found that stiffer tissue can cause pancreatic cancer cells to become resistant to chemotherapy, while softer tissue made the cancer cells ...

Multidrug resistance genes screening of pancreatic ductal ...

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancer types and chemotherapeutic drug resistance is a stumbling block in ...

Culprits of PDAC resistance to gemcitabine and immune checkpoint ...

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal cancer with a dismal five-year survival rate of 11%.

Hypoxia-induced epigenetic regulation of miR-485-3p promotes ...

The mechanism of hypoxia in chemoresistance of pancreatic ductal adenocarcinoma (PDAC) remains elusive. In this study, we revealed the ...

Pancreatic Cancer Chemoresistance to Gemcitabine - MDPI

Development of tumor resistance to gemcitabine critically limits the efficacy of this cornerstone of pancreatic cancer chemotherapy. Chemoresistance can be ...

Gemcitabine resistance of pancreatic cancer cells is mediated by ...

Chemoresistance in pancreatic cancer cells may be caused by the expansion of inherently resistant cancer cells or by the adaptive plasticity ...

Tumor Microenvironment Features and Chemoresistance in ... - MDPI

Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis. The lack of early diagnosis and the absence of suitable biomarkers coupled with ...

Impact of CD36 on Chemoresistance in Pancreatic Ductal ...

Pancreatic ductal adenocarcinoma (PDAC) is a fatal neoplasm with a poor prognosis.1,2 Many patients are not diagnosed until PDAC reaches an ...

Pancreatic ductal adenocarcinoma chemoresistance

This review summarizes how PC develops chemoresistance through aberrations in biochemical metabolism and discusses novel critical targets and pathways within ...

Overcoming chemoresistance by targeting reprogrammed metabolism

Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related death due to its late diagnosis that removes the ...

Mechanisms of drug resistance of pancreatic ductal ... - Portland Press

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death worldwide, and the mortality of patients with PDAC has not ...

Pancreatic cancer: new approach could reverse chemo resistance

Pancreatic cancer is a particularly aggressive and difficult-to-treat cancer, in part because it is often resistant to chemotherapy.

Drug resistance in pancreatic cancer: New player caught in act

∙ et al. Impact of intensified chemotherapy in metastatic pancreatic ductal adenocarcinoma (PDAC) in clinical routine in Europe. Pancreatology. 2019; 19:97 ...

The Current Treatment Paradigm for Pancreatic Ductal ... - Frontiers

As mentioned, nearly all intent-to-treat patients will receive multi-agent chemotherapy. This has long been the backbone of pancreatic cancer management. While ...

Abstract 1190 Investigating chemoresistance mechanisms and ...

Despite great effort in the development of treatment strategies for pancreatic ductal adenocarcinoma (PDAC), response rates to current gold standard ...

Overcoming chemoresistance by targeting reprogrammed metabolism

Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer ... Molecular and cellular mechanisms of chemoresistance in pancreatic cancer.

Chemoresistance in pancreatic ductal adenocarcinoma. Increased...

Chemoresistance in pancreatic ductal adenocarcinoma. Increased pro-inflammatory cytokines, extracellular matrix remodeling of the stroma, ...