Chimeric Livers

Chimeric Mice with Humanized Liver: Tools for the Study of Drug ...

Fig. 27.1. ... Humanized mouse liver model (FRG). A deficiency in Fah activity leads to the accumulation of metabolites of tyrosine that are toxic to native ...

Generation of Human Liver Chimeric Mice and Harvesting ... - PubMed

Fah-/-/Rag2-/-/Il2rg-/- (FRG) mice are proven to be an ideal bioincubator for repopulation of PHHs. The human liver chimeric FRG mouse is not only a humanized ...

A human liver chimeric mouse model for non-alcoholic fatty liver ...

This humanised NAFLD model is a physiologically relevant, experimentally tractable model for the study of steatosis.

Functional mouse hepatocytes derived from interspecies chimeric ...

Functional mouse hepatocytes derived from interspecies chimeric livers effectively mitigate chronic liver fibrosis.

Mice with Chimeric Livers Are an Improved Model for Human ... - PLOS

These data indicate that chimeric FRG-mice are a useful new model for human lipoprotein and bile-acid metabolism.

Chimeric Livers and Cross-Species Cures - Dove Medical Press

Blastocyst complementation harbors notable potential for generating complete human livers in large animals, which could be used for ...

Characterization and applications of chimeric mice with humanized ...

We have succeeded in stable mass production of chimeric PXB-mice, whose liver is repopulated by human hepatocytes at a ratio of more than 70%.

Hepatitis C virus replication in mice with chimeric human livers

Lack of a small animal model of the human hepatitis C virus (HCV) has impeded development of antiviral therapies against this epidemic infection.

Utility of Chimeric Mice with Humanized Livers for Predicting Hepatic ...

The data support that the chimeric mice with humanized livers could be a useful tool for the prediction of hepatic OATP1B-mediated DDIs in humans.

Mice With Human Livers - Gastroenterology

Keywords: Hepatocyte; Liver; Chimera; Humanization;. Animal Model. Chimeric mice harboring human cells have long been used in research. The first examples were ...

New applications of chimeric mice with humanized livers

Unfortunately, little is known about the metabolic capacity of cultivated human hepatocytes compared to their performance in chimeric mouse ...

Generation of Novel Chimeric Mice with Humanized Livers by Using ...

These results indicate that hemizygous cDNA-uPA/SCID mice may be novel and useful hosts for producing chimeric mice for use in future long-term studies.

Chimeric Livers: Interspecies Blastocyst Complementation and ...

This review compiles the current understanding of interspecies blastocyst complementation and outlines future possibilities for liver xenotransplantation in ...

Chimeric mice with humanized liver - ScienceDirect.com

We thought that chimeric mice with humanized liver could become a new tool for estimating the human toxicity and pharmacokinetics.

Morphological and microarray analyses of human hepatocytes from ...

The chimeric livers were constructed with h-heps, mouse hepatocytes, and mouse hepatic sinusoidal cells (m-HSCs). Here, we investigated the ...

A step closer to solving the problem of transplantable organ shortage?

Chimeric mice livers in rat body required up to two months before rat hepatocytes fully colonized the mouse liver, in addition transdifferentiation of the ...

Chimeric Mice With Humanized Livers Demonstrate Human-Specific ...

In this study, we investigated the hepatotoxicity caused by KMTR2, an anti-human TRAIL-R2 monoclonal antibody, in chimeric mice with humanized livers (PXB-mice ...

Human liver chimeric mice provide a model for hepatitis B and ... - JCI

This human liver chimeric mouse model will expand the experimental possibilities for studying HBV and HCV infection, and possibly other human ...

Hepatocyte-targeted siTAZ therapy lowers liver fibrosis in NASH diet ...

We used NASH diet-fed chimeric mice reconstituted with human hepatocytes (hu-liver mice) to test a mechanism-based hepatocyte-targeted small interfering RNA ( ...

Human Liver Chimeric Mice (HepMice) - Invivocue

The accumulation of lipids in hepatocytes is a hallmark feature of fatty liver disease. Treatment of human hepatocytes with increasing concentration of oleic ...